skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Indium 111-labeled platelet kinetic studies and platelet-associated IgG in hairy cell leukemia

Abstract

In order to study the pathogenesis of thrombocytopenia in patients with hairy cell leukemia (HCL), levels of platelet-associated IgG (PAIgG), platelet life span (MLS), and the sequestration site of autologous /sup 111/In-labeled platelets were measured in nine patients with HCL. Splenectomized patients (n = 4) had a higher platelet count (x = 122.5 X 10(9)/l; range, 80-190 X 10(9)/l) as well as higher levels of PAIgG (x = 10.7%; range, 5.8-16.9%), than nonsplenectomized patients (platelets x = 76 X 10(9)/l, range 40-100 X 10(9)/l; PAIgG x = 3.2%, range 2.2-4.2%). A normal recovery of /sup 111/In-labeled platelets was found in splenectomized patients, whereas a very low recovery was observed in the nonsplenectomized group (x = 70.2%, range, 50-82.5%, versus x = 22.4%, range, 15-28.2%). The MLS was borderline normal in all patients. The site of sequestration was the spleen in nonsplenectomized patients. The low recovery of /sup 111/In-labeled platelets in nonsplenectomized patients suggests hypersplenism with pooling as a major cause of thrombocytopenia, in addition to impaired thrombocytopoiesis and possible immune-mediated platelet destruction.

Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
5013808
Resource Type:
Journal Article
Journal Name:
Cancer (Philadelphia); (United States)
Additional Journal Information:
Journal Volume: 2
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; LEUKEMIA; PATHOGENESIS; BLOOD PLATELETS; CELL DIVISION; IMMUNOGLOBULINS; INDIUM 111; PATIENTS; SPLENECTOMY; TRACER TECHNIQUES; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; DAYS LIVING RADIOISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; GLOBULINS; HEMIC DISEASES; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MATERIALS; MEDICINE; MINUTES LIVING RADIOISOTOPES; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PROTEINS; RADIOISOTOPES; SURGERY; 550901* - Pathology- Tracer Techniques

Citation Formats

Panzer, S, Lechner, K, Neumann, E, Meryn, S, and Haubenstock, A. Indium 111-labeled platelet kinetic studies and platelet-associated IgG in hairy cell leukemia. United States: N. p., 1986. Web. doi:10.1002/1097-0142(19860715)58:2<234::AID-CNCR2820580206>3.0.CO;2-E.
Panzer, S, Lechner, K, Neumann, E, Meryn, S, & Haubenstock, A. Indium 111-labeled platelet kinetic studies and platelet-associated IgG in hairy cell leukemia. United States. https://doi.org/10.1002/1097-0142(19860715)58:2<234::AID-CNCR2820580206>3.0.CO;2-E
Panzer, S, Lechner, K, Neumann, E, Meryn, S, and Haubenstock, A. 1986. "Indium 111-labeled platelet kinetic studies and platelet-associated IgG in hairy cell leukemia". United States. https://doi.org/10.1002/1097-0142(19860715)58:2<234::AID-CNCR2820580206>3.0.CO;2-E.
@article{osti_5013808,
title = {Indium 111-labeled platelet kinetic studies and platelet-associated IgG in hairy cell leukemia},
author = {Panzer, S and Lechner, K and Neumann, E and Meryn, S and Haubenstock, A},
abstractNote = {In order to study the pathogenesis of thrombocytopenia in patients with hairy cell leukemia (HCL), levels of platelet-associated IgG (PAIgG), platelet life span (MLS), and the sequestration site of autologous /sup 111/In-labeled platelets were measured in nine patients with HCL. Splenectomized patients (n = 4) had a higher platelet count (x = 122.5 X 10(9)/l; range, 80-190 X 10(9)/l) as well as higher levels of PAIgG (x = 10.7%; range, 5.8-16.9%), than nonsplenectomized patients (platelets x = 76 X 10(9)/l, range 40-100 X 10(9)/l; PAIgG x = 3.2%, range 2.2-4.2%). A normal recovery of /sup 111/In-labeled platelets was found in splenectomized patients, whereas a very low recovery was observed in the nonsplenectomized group (x = 70.2%, range, 50-82.5%, versus x = 22.4%, range, 15-28.2%). The MLS was borderline normal in all patients. The site of sequestration was the spleen in nonsplenectomized patients. The low recovery of /sup 111/In-labeled platelets in nonsplenectomized patients suggests hypersplenism with pooling as a major cause of thrombocytopenia, in addition to impaired thrombocytopoiesis and possible immune-mediated platelet destruction.},
doi = {10.1002/1097-0142(19860715)58:2<234::AID-CNCR2820580206>3.0.CO;2-E},
url = {https://www.osti.gov/biblio/5013808}, journal = {Cancer (Philadelphia); (United States)},
number = ,
volume = 2,
place = {United States},
year = {Tue Jul 15 00:00:00 EDT 1986},
month = {Tue Jul 15 00:00:00 EDT 1986}
}