Experimental myocardial ischemia. Pt. 2

Journal Article · Fri Jan 01 00:00:00 EST 1982 · Cardiovasc. Interv. Radiol.; (United States)

DOI:https://doi.org/10.1007/BF02552312· OSTI ID:5011980

Serur, J R; Als, A V; Paulin, S

The comparative effects of meglumine sodium diatrizoate (MSD), sodium meglumine calcium metrizoate (SMCM), and metrizamide (M) were studied in an isolated canine heart preparation. The parameters observed were coronary blood flow (CBF), myocardial contractile force (MCF), positive and negative dF/dt, and perfusion pressure during normal and ischemic perfusion conditions. MSD had an initial negative inotropic effect but baseline MCF returned in 1 min during normal perfusion and 2 min under ischemic conditions. SMCM and M had only a positive inotropic effect under normal perfusion. However, during ischemia, the positive effect of SMCM was followed by a decrease in contractile force. M showed only a positive effect on force during ischemia. Our results indicate that calcium additive may increase the risk of coronary arteriography in patients with severe coronary artery disease.

• OSTI ID: 5011980
• Journal Information: Cardiovasc. Interv. Radiol.; (United States), Vol. 5:3/4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CONTRAST MEDIA
SIDE EFFECTS
ISCHEMIA
DIAGNOSIS
MYOCARDIUM
BIOMEDICAL RADIOGRAPHY
BLOOD FLOW
COMPARATIVE EVALUATIONS
DOGS
DYNAMIC FUNCTION STUDIES
TOXICITY
X-RAY RADIOGRAPHY
ANIMALS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DIAGNOSTIC TECHNIQUES
DISEASES
HEART
INDUSTRIAL RADIOGRAPHY
MAMMALS
MEDICINE
MUSCLES
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
VASCULAR DISEASES
VERTEBRATES
550602* - Medicine- External Radiation in Diagnostics- (1980-)