Effects of lead on the kidney: Roles of high-affinity lead-binding proteins

Journal Article · Fri Feb 01 00:00:00 EST 1991 · Environmental Health Perspectives; (United States)

DOI:https://doi.org/10.1289/ehp.919177· OSTI ID:5010604

Fowler, B A ^[1]; DuVal, G ^[2]

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1. Univ. of Maryland, Baltimore (United States)
2. Univ of Maryland Medical School, Baltimore (United States)

Lead-induced nephropathy produces both tubular and interstitial manifestations of cell injury, but the pathophysiology of these lesions is not completely understood. Delineation of the molecular factors underlying renal handling of lead is one of central importance in understanding the mechanisms of renal cell injury from this agent. Recent studies from this laboratory have identified several distinct high-affinity lead-binding proteins (PbBP) from rat kidney and brain that appear to play critical roles in the intracellular bioavailability of lead to several essential cellular processes in these target tissues at low dose levels. These studies have also shown that the real PbBP is selectively localized in only certain nephrons and only specific segments of the renal proximal tubule. The striking nephron and cell-type specificity of the localization reaction could result from physoiological differences in nephron functional activity or selective molecular uptake mechanisms/metabolism differences that act to define target cell populations in the kidney. In addition, other preliminary studies have shown that short-term, high-dose lead exposure produces increased excretion of this protein into the urine with concomitant decreases in renal concentrations.

• OSTI ID: 5010604
• Journal Information: Environmental Health Perspectives; (United States), Vol. 91; ISSN 0091-6765
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
KIDNEYS
CYTOCHEMISTRY
LEAD COMPOUNDS
EXCRETION
MEMBRANE PROTEINS
PURIFICATION
ANTIBODIES
BIOLOGICAL EFFECTS
CHRONIC EXPOSURE
GLOBULINS
URINE
BIOCHEMISTRY
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CHEMISTRY
CLEARANCE
MATERIALS
ORGANIC COMPOUNDS
ORGANS
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