Strategies for epidemiologic studies of lead in bone in occupationally exposed populations
- Mount Sinai School of Medicine, New York, NY (United States)
Lead exposure is widespread among industrial populations in the US. X-ray fluorescence (XRF) analysis of the lead content of bone offers a promising approach to acquisition of individualized data on chronic lead absorption in occupationally exposed populations. Dosimetric data obtained by XRF will permit accurate definition of dose-response relationships for such chronic consequences of lead exposure as central and peripheral neurologic impairment, renal disease, hypertension, and possibly reproductive dysfunction. Additionally, data on bone lead contect obtained by XRF will permit validation of models describing the body lead burden and will allow direct assessment of the efficacy of therapeutic chelation. XRF data may also permit assessment of the possible role of genetic polymorphism of the enzyme delta-aminolevulinic dehydrase as a determinant of the pharmacokinetics and toxicity of lead. In both cross-sectional and prospective epidemiologic studies of body lead burden in occupationally exposed populations, the K-XRF instrument appears to be the technology of choice.
- OSTI ID:
- 5010598
- Journal Information:
- Environmental Health Perspectives; (United States), Vol. 91; ISSN 0091-6765
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LEAD COMPOUNDS
OCCUPATIONAL EXPOSURE
SKELETON
X-RAY FLUORESCENCE ANALYSIS
BODY BURDEN
BRAIN
CONCENTRATION RATIO
GENETIC VARIABILITY
HUMAN POPULATIONS
KIDNEYS
PHARMACOLOGY
REPRODUCTION
RFLPS
BIOLOGICAL VARIABILITY
BODY
CENTRAL NERVOUS SYSTEM
CHEMICAL ANALYSIS
NERVOUS SYSTEM
NONDESTRUCTIVE ANALYSIS
ORGANS
POPULATIONS
X-RAY EMISSION ANALYSIS
560300* - Chemicals Metabolism & Toxicology