Tomographic imaging of the human thyroid using /sup 124/I
After receiving between 100 and 300 mu Ci of the positron-emitting radioisotope /sup 124/I (half-life, 4.2 days), 64 patients with a variety of thyroid disorders were imaged with a high resolution positron camera. A 3-dimensional image of the distribution of radi,iodine uptake within the thyroid was obtained from a single 10- to 15-min scan. This image may be viewed as a sequence of 2-mm thick transverse, sagittal, or frontal sections or as a 3-dimensional shaded surface. The functional volume of the thyroid may be estimated by counting the volume elements (voxels) inside the thyroid surface. The precision of the estimate varied from 6-15%, depending on the size and clinical status of the thyroid. The volume estimation procedure was validated with phantoms and with the thyroids of patients who subsequently underwent partial thyroidectomy. This 3-dimensional imaging technique may be useful for diagnosis and management of thyroid diseases.
- Research Organization:
- Univ. Hospital of Geneva, Switzerland
- OSTI ID:
- 5008134
- Journal Information:
- J. Clin. Endocrinol. Metab.; (United States), Vol. 4
- Country of Publication:
- United States
- Language:
- English
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IODINE 124
DIAGNOSTIC USES
THYROID
POSITRON COMPUTED TOMOGRAPHY
GOITER
PATIENTS
PHANTOMS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MOCKUP
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
STRUCTURAL MODELS
TOMOGRAPHY
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics