Proton and fluorine NMR imaging for the assessment of myocardial perfusion
A high field, small bore NMR spectrometer was converted to an imaging system for the detection of fluorine and protons in phantoms and small biological samples. The modified spectrometer system was used to image various phantoms for the assessment of imaging performance. After assessment of the imaging system performance, a water soluble fluorinated compound of relatively low toxicity was investigated for use as an imaging agent for the detection of myocardial perfusion. New Zealand white rabbits were used as the model. Hearts were rapidly extracted and hung via the aorta to a perfusion apparatus which was capable of prolonging heart function throughout the course of the experiment. Perfusion with a standard nutrient solution was followed either by perfusion with a solution to which the fluorinated compound had been added or by ligation of the left coronary artery with subsequent perfusion with the fluorinated compound in perfusate solution. The hearts were then sectioned and imaged. The ligation of the left coronary artery produced a region of impaired perfusion in the left ventricular wall and parts of the septum. The regions of reduced perfusion appeared in the F-19 NMR images as areas of reduced intensity. Proton images of the tissue sections were also obtained for comparison. It was found that infarcted regions may be best visualized by combining the fluorine and proton images. Infarct damage was verified by Gentian violet stain. Relaxation times of fluorine and protons were measured both in perfused tissue and in various concentration solutions.
- OSTI ID:
- 5007620
- Resource Relation:
- Other Information: Thesis
- Country of Publication:
- United States
- Language:
- English
Similar Records
Scintigraphic assessment of sympathetic innervation after transmural versus nontransmural myocardial infarction
Regional myocardial perfusion of cardioplegic solutions
Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
MYOCARDIAL INFARCTION
DIAGNOSIS
MYOCARDIUM
DYNAMIC FUNCTION STUDIES
NUCLEAR MAGNETIC RESONANCE
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
CORONARIES
FLUORINE 19
HEART
PERFUSED ORGANS
PHANTOMS
PROTONS
RABBITS
ANIMALS
ARTERIES
BARYONS
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DISEASES
DRUGS
ELEMENTARY PARTICLES
FERMIONS
FLUORINE ISOTOPES
HADRONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAGNETIC RESONANCE
MAMMALS
MOCKUP
MUSCLES
NUCLEI
NUCLEONS
ODD-EVEN NUCLEI
ORGANS
RESONANCE
STABLE ISOTOPES
STRUCTURAL MODELS
SYNTHESIS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials