Local variation in cutaneous and subcutaneous blood flow measured by CdTe(C1) minidetectors in normal and psoriatic skin
The accuracy of the /sup 133/Xe washout method and the validity of newly developed cadmium telluride CdTe(Cl) minisemiconductor detectors were estimated by performing comparative, simultaneous measurements of both cutaneous (CBF) and subcutaneous (SBF) blood flow using 2 conventional scintillation sodium iodide NaI(Tl) and CdTe(Cl) detectors over the same radioactive depot in each of 10 individuals. The accuracy of the /sup 133/Xe washout method was found to be 13-15% (C.V.) for the CBF measurements and 9-12% (C.V.) for the SBF measurements. The CdTe(Cl) detectors, which have a weight of 20 g and were attached directly over the radioactive depot, may replace stationary NaI(Tl) detectors placed 20 cm from the depot for measurements of both CBF and SBF. Two CdTe(Cl) detectors were used for estimations of the local variation in CBF and SBF within a distance of 5 cm in normal skin of 10 individuals. The C.V. was 7% for the CBF measurements and 18% for the SBF measurements. Measurements of CBF and SBF were performed in 6 psoriatic patients who developed typical Woronoff rings. The local CBF differed significantly from the center of psoriatic plaques to the margin, in the Woronoff ring, and in nonlesional skin. In contrast, SBF was remarkably equal within the plaque and in the Woronoff ring. Cutaneous blood flow in chronic stable, lesional psoriatic skin was significantly lower than previously published values for active lesional psoriatic skin, but significantly higher than CBF in normal individuals. Measurements of CBF in tetrahydrofurfuryl nicotinic acid (Trafuril)-treated skin showed higher values than measurements of CBF in the postischemic hyperemia period both in normal and in lesional psoriatic skin. Trafuril induced a significant increase of CBF in both lesional and nonlesional skin.
- Research Organization:
- Finsen Institute, Copenhagen, Denmark
- OSTI ID:
- 5007564
- Journal Information:
- J. Invest. Dermatol.; (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
Similar Records
Cutaneous blood flow in psoriasis
Regulation of local subcutaneous blood flow in patients with psoriasis and effects of antipsoriatic treatment on subcutaneous blood flow
Related Subjects
BLOOD FLOW
MEASURING METHODS
SKIN
ACCURACY
CADMIUM TELLURIDES
ISCHEMIA
PATIENTS
PSORIASIS
SEMICONDUCTOR DETECTORS
TELLURIUM
XENON 133
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CADMIUM COMPOUNDS
CARDIOVASCULAR DISEASES
CHALCOGENIDES
DAYS LIVING RADIOISOTOPES
DISEASES
ELEMENTS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEASURING INSTRUMENTS
NUCLEI
ORGANS
RADIATION DETECTORS
RADIOISOTOPES
SEMIMETALS
SKIN DISEASES
TELLURIDES
TELLURIUM COMPOUNDS
VASCULAR DISEASES
XENON ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics