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Title: Increased albumin permeation in eyes, aorta, and kidney of hypertensive rats fed galactose

Abstract

These experiments were undertaken to determine whether ingestion of galactose increases albumin permeation in the vasculature of hypertensive rats. 50% dextrin (control) or 50% galactose diets were fed to unilaterally nephrectomized, male Sprague-Dawley rats weighing 200 g. Hypertension (systolic pressure >175 mmHg) was induced by weekly IM injections of 25 mg/kg DOCA and 1% saline drinking water; 3 months later /sup 125/I-albumin permeation was assessed in whole eyes, aorta and kidneys. /sup 125/I-albumin permeation was significantly increased in all 3 tissues of hypertensive rats (n = 9) vs controls (n = 9): aorta (3.30 +/- 0.19 (SD) vs 2.87 +/- 0.14), eye (3.15 +/- 0.14 vs 2.59 +/- 0.11), and kidney (6.58 +/- 0.63 vs 3.85 +/- 0.50). Albumin permeation was increased still further in hypertensive rats fed the galactose diet (n = 8): aorta (3.75 +/- 0.38), eye (3.82 +/- 0.17), and kidney (10.74 +/- 3.13). Hypertension +/- galactose feeding had no effect on albumin permeation in lung, skin, or brain. These findings indicate that: (1) hypertension increases albumin permeation in vessels affected by diabetic vascular diseases, and 2) hypertension-induced increases in albumin permeation are increased still further by galactose ingestion, presumably mediated by imbalances in polyol/insitol metabolism (analogousmore » to those induced by diabetes) independent of hyperglycemia and/or insulinopenia.« less

Authors:
; ; ; ;
Publication Date:
Research Org.:
Washington Univ. School of Medicine, St. Louis, MO
OSTI Identifier:
5006521
Report Number(s):
CONF-8604222-
Journal ID: CODEN: FEPRA; TRN: 86-037029
Resource Type:
Conference
Journal Name:
Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
Additional Journal Information:
Journal Volume: 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ALBUMINS; TISSUE DISTRIBUTION; GALACTOSE; BIOLOGICAL EFFECTS; HYPERTENSION; PATHOGENESIS; AORTA; BRAIN; DIET; EYES; IODINE 125; KIDNEYS; LUNGS; NEPHRECTOMY; PERMEABILITY; RATS; SKIN; TRACER TECHNIQUES; ALDEHYDES; ANIMALS; ARTERIES; BETA DECAY RADIOISOTOPES; BLOOD VESSELS; BODY; BODY AREAS; CARBOHYDRATES; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; DAYS LIVING RADIOISOTOPES; DISEASES; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; FACE; HEAD; HEXOSES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MEDICINE; MONOSACCHARIDES; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPES; RESPIRATORY SYSTEM; RODENTS; SACCHARIDES; SENSE ORGANS; SURGERY; SYMPTOMS; VASCULAR DISEASES; VERTEBRATES; 550901* - Pathology- Tracer Techniques

Citation Formats

Tilton, R G, LaRose, L, Chang, K, Weigel, C J, and Williamson, J R. Increased albumin permeation in eyes, aorta, and kidney of hypertensive rats fed galactose. United States: N. p., 1986. Web.
Tilton, R G, LaRose, L, Chang, K, Weigel, C J, & Williamson, J R. Increased albumin permeation in eyes, aorta, and kidney of hypertensive rats fed galactose. United States.
Tilton, R G, LaRose, L, Chang, K, Weigel, C J, and Williamson, J R. 1986. "Increased albumin permeation in eyes, aorta, and kidney of hypertensive rats fed galactose". United States.
@article{osti_5006521,
title = {Increased albumin permeation in eyes, aorta, and kidney of hypertensive rats fed galactose},
author = {Tilton, R G and LaRose, L and Chang, K and Weigel, C J and Williamson, J R},
abstractNote = {These experiments were undertaken to determine whether ingestion of galactose increases albumin permeation in the vasculature of hypertensive rats. 50% dextrin (control) or 50% galactose diets were fed to unilaterally nephrectomized, male Sprague-Dawley rats weighing 200 g. Hypertension (systolic pressure >175 mmHg) was induced by weekly IM injections of 25 mg/kg DOCA and 1% saline drinking water; 3 months later /sup 125/I-albumin permeation was assessed in whole eyes, aorta and kidneys. /sup 125/I-albumin permeation was significantly increased in all 3 tissues of hypertensive rats (n = 9) vs controls (n = 9): aorta (3.30 +/- 0.19 (SD) vs 2.87 +/- 0.14), eye (3.15 +/- 0.14 vs 2.59 +/- 0.11), and kidney (6.58 +/- 0.63 vs 3.85 +/- 0.50). Albumin permeation was increased still further in hypertensive rats fed the galactose diet (n = 8): aorta (3.75 +/- 0.38), eye (3.82 +/- 0.17), and kidney (10.74 +/- 3.13). Hypertension +/- galactose feeding had no effect on albumin permeation in lung, skin, or brain. These findings indicate that: (1) hypertension increases albumin permeation in vessels affected by diabetic vascular diseases, and 2) hypertension-induced increases in albumin permeation are increased still further by galactose ingestion, presumably mediated by imbalances in polyol/insitol metabolism (analogous to those induced by diabetes) independent of hyperglycemia and/or insulinopenia.},
doi = {},
url = {https://www.osti.gov/biblio/5006521}, journal = {Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)},
number = ,
volume = 45:3,
place = {United States},
year = {Sat Mar 01 00:00:00 EST 1986},
month = {Sat Mar 01 00:00:00 EST 1986}
}

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