skip to main content

Title: Search for mutations affecting protein structure in children of atomic bomb survivors: preliminary report

A total of 289,868 locus tests, based on 28 different protein phenotypes and using one-dimensional electrophoresis to detect variant proteins, has yielded one probable mutation in the offspring of proximally exposed parents, who received an estimated average gonadal exposure of 31 to 39 rem in the atomic bombings of Hiroshima and Nagasaki. There were no mutations in 208,196 locus tests involving children of distally exposed parents, who had essentially no radiation exposure.
Authors:
 [1] ; ; ; ; ; ; ; ;
  1. (Univ. of Michigan, Ann Arbor)
Publication Date:
OSTI Identifier:
5006255
Resource Type:
Journal Article
Resource Relation:
Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States); Journal Volume: 77:7
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; A-BOMB SURVIVORS; GENETIC RADIATION EFFECTS; CHILDREN; PROTEINS; GENETIC VARIABILITY; DELAYED RADIATION EFFECTS; DOSE-RESPONSE RELATIONSHIPS; ELECTROPHORESIS; EPIDEMIOLOGY; GENES; HIROSHIMA; MOLECULAR STRUCTURE; MUTATIONS; NAGASAKI; PHENOTYPE; RADIATION DOSES; AGE GROUPS; ANIMALS; ASIA; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL VARIABILITY; DOSES; GENETIC EFFECTS; JAPAN; MAMMALS; MAN; ORGANIC COMPOUNDS; PRIMATES; RADIATION EFFECTS; VERTEBRATES 560151* -- Radiation Effects on Animals-- Man; 550400 -- Genetics; 550200 -- Biochemistry