Effect of radiation-induced reduction of nitroimidazoles on biologically active DNA

Journal Article · Tue Jul 01 00:00:00 EDT 1986 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(86)90260-9· OSTI ID:5006198

Lafleur, M V; Pluijmackers-Westmijze, E J; Loman, H

Radiation-chemical reductions have been carried out with several nitroimidazoles. Reduction of these drugs in the presence of single-stranded phi chi 174 DNA causes extensive lethal damage. However, relatively stable (end) products, do not contribute to the damage, although glyoxal is potentially toxic. This demonstrates that a short-lived intermediate in the reduction process is responsible. Further, the quantity of damage in the DNA depends on both dose (reduction)-rate and also the nature of the drug.

• Research Organization: Vrije Universiteit, Amsterdam, The Netherlands
• OSTI ID: 5006198
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 7
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
IMIDAZOLES
BIOLOGICAL EFFECTS
CHEMICAL RADIATION EFFECTS
DNA
METRONIDAZOLE
MISONIDAZOLE
NITRO COMPOUNDS
RADIOCHEMISTRY
RADIOSENSITIZERS
REDUCTION
TOXICITY
ALCOHOLS
ANTINEOPLASTIC DRUGS
AZOLES
CHEMICAL REACTIONS
CHEMISTRY
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION CHEMISTRY
RADIATION EFFECTS
560111* - Radiation Effects on Biochemicals- In Vitro- (-1987)
400600 - Radiation Chemistry