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Title: Induction of allogeneic unresponsiveness by supralethal irradiation and bone marrow reconstitution. [Dogs]

Supralethally irradiated dogs were reconstituted wth their own stored bone marrow and were challenged at various time intervals with a kidney allograft. The data suggest that transplanted bone marrow cells may participate directly in the events leading to allogenic unresponsiveness. The time interval between marrow cell replacement and kidney allotransplantation required for optimal results suggest that at least one cycle of cell turnover by the replaced stem cells is needed in order to produce unresponsiveness. Host irradiation and reconstitution with stored autologous marrow may be useful in the treatment of certain forms of cancer.
Authors:
; ; ;
Publication Date:
OSTI Identifier:
5005521
Resource Type:
Journal Article
Resource Relation:
Journal Name: Transplant. Proc.; (United States); Journal Volume: 12:3
Research Org:
State University of New York, Stony Brook
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; GRAFT-HOST REACTION; BIOLOGICAL RADIATION EFFECTS; IMMUNOSUPPRESSION; RADIOINDUCTION; BONE MARROW CELLS; DOGS; GRAFTS; IMMUNITY; KIDNEYS; SKIN; SUPRALETHAL IRRADIATION; TRANSPLANTS; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BODY; CONNECTIVE TISSUE CELLS; IRRADIATION; MAMMALS; ORGANS; RADIATION EFFECTS; SOMATIC CELLS; VERTEBRATES 560152* -- Radiation Effects on Animals-- Animals; 550603 -- Medicine-- External Radiation in Therapy-- (1980-)