Study of the effects of lead and light on the retina
Lipid peroxidation is one of the mechanisms by which lead may produce toxic effects. Since the retina possesses characteristics which may cause it to be susceptible to lipid peroxidation, the effects of lead on the rabbit retina were investigated. Changes were found in several indicators of lipid peroxidation including malonaldehyde levels and extractable fluorescence. Histologic and ultrastructural evaluations showed accumulation of lipofuscin and disruption of retinal architecture. The effect of concurrent constant light was also tested and was found to be a modification of the effects produced by lead, probably mediated through a disruption of normal retinal physiology. A decrease in catalase activity was seen in the retinas of lead-exposed animals. Concurrent constant light treatment added to this inhibition. These findings suggest that lead can produce peroxidation effects in the eye and that the retina may be highly susceptible to peroxidated damage.
- Research Organization:
- Cincinnati Univ., OH (USA)
- OSTI ID:
- 5001264
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LEAD COMPOUNDS
BIOLOGICAL EFFECTS
RETINA
ENZYME ACTIVITY
VISIBLE RADIATION
CATALASE
OXIDATION
RABBITS
ANIMALS
BODY
BODY AREAS
CHEMICAL REACTIONS
ELECTROMAGNETIC RADIATION
ENZYMES
EYES
FACE
HEAD
MAMMALS
ORGANS
OXIDOREDUCTASES
PEROXIDASES
RADIATIONS
SENSE ORGANS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)