The d4 gene family in the human genome

Journal Article · Thu Aug 15 00:00:00 EDT 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0440· OSTI ID:484340

Chestkov, A V; Baka, I D; Kost, M V ^[1]

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1. Engelhardt Inst. of Molecular Biology, Moscow (Russian Federation); and others

The d4 domain, a novel zinc finger-like structural motif, was first revealed in the rat neuro-d4 protein. Here we demonstrate that the d4 domain is conserved in evolution and that three related genes form a d4 family in the human genome. The human neuro-d4 is very similar to rat neuro-d4 at both the amino acid and the nucleotide levels. Moreover, the same splice variants have been detected among rat and human neuro-d4 transcripts. This gene has been localized on chromosome 19, and two other genes, members of the d4 family isolated by screening of the human genomic library at low stringency, have been mapped to chromosomes 11 and 14. The gene on chromosome 11 is the homolog of the ubiquitously expressed mouse gene ubi-d4/requiem, which is required for cell death after deprivation of trophic factors. A gene with a conserved d4 domain has been found in the genome of the nematode Caenorhabditis elegans. The conservation of d4 proteins from nematodes to vertebrates suggests that they have a general importance, but a diversity of d4 proteins expressed in vertebrate nervous systems suggests that some family members have special functions. 11 refs., 2 figs.

• OSTI ID: 484340
• Journal Information: Genomics, Vol. 36, Issue 1; Other Information: PBD: 15 Aug 1996
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
GENES
BIOLOGICAL EVOLUTION
SPLICING
TRANSCRIPTION
GENETIC MAPPING
GENE REGULATION
STRUCTURE-ACTIVITY RELATIONSHIPS
DNA-CLONING
DNA SEQUENCING
HUMAN CHROMOSOME 19
B CODES
HUMAN CHROMOSOMES
HUMAN CHROMOSOME 14
HEREDITARY DISEASES
ETIOLOGY
PROTEINS
AMINO ACID SEQUENCE
NUCLEOTIDES
POLYMERASE CHAIN REACTION
DNA HYBRIDIZATION
RATS
COSMIDS
PROBES
FLUORESCENCE