Relationship between the monosomy X phenotype and Y-linked ribosomal protein S4 (Rps4) in several species of mammals: A molecular evolutionary analysis of Rps4 homologs
- Yamagata Univ. School of Medicine (Japan)
Two isoforms of the human ribosomal protein S4 gene, RPS4X and RPS4Y, are located on the X and Y chromsomes. It has been postulated and haploinsufficiency of these genes may contribute to Turner syndrome. We show here that several animal species that show the Turner-like phenotype on monosomy X have no Y-linked Rps4 homolog. There may be another gene(s) that contributes to abnormal phenotypes of monosomy X. Molecular evolutionary analysis shows that the Y-linked and RPS4X-related homologs diverged prior to the radiation of placental mammals and evolved independently. Furthermore, the functional constraints against the RPS4X-related homologs are much stronger than those against the Y-linked homologs. 37 refs., 3 figs., 1 tab.
- OSTI ID:
- 478832
- Journal Information:
- Genomics, Vol. 31, Issue 1; Other Information: PBD: 1 Jan 1996
- Country of Publication:
- United States
- Language:
- English
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