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Title: Human synaptonemal complex protein 1 (SCP1): Isolation and characterization of the cDNA and chromosomal localization of the gene

Abstract

Synaptonemal complexes (SCs) are structures that are formed between homologous chromosomes (homologs) during meiotic prophase. They consist of two proteinaceous axes, one along each homolog, that are connected along their length by numerous transverse filaments (TFs). The cDNA encoding one major component of TFs of SCs of the rat, rnSCP1, has recently been isolated and characterized. In this paper we describe the isolation and characterization of the cDNA encoding the human protein homologous to rnSCP1, hsSCP1. hsSCP1 and rnSCP1 have 75% amino acid identity. The most prominent structural features and amino acid sequence motifs of rnSCP1 have been conserved in hsSCP1. Most probably, hsSCP1 is functionally homologous to rnSCP1. The hsSCP1 gene was assigned to human chromosome 1p12-p13 by fluorescence in situ hybridization. 44 refs., 4 figs.

Authors:
; ;  [1]
  1. Agricultural Univ., Wageningen (Netherlands); and others
Publication Date:
OSTI Identifier:
476889
Resource Type:
Journal Article
Journal Name:
Genomics
Additional Journal Information:
Journal Volume: 39; Journal Issue: 3; Other Information: PBD: 1 Feb 1997
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; PROTEINS; GENETIC MAPPING; DNA SEQUENCING; DNA-CLONING; STRUCTURE-ACTIVITY RELATIONSHIPS; HUMAN CHROMOSOME 1; MEIOSIS; ANIMAL CELLS; DIPLOIDY; HAPLOIDY; LIFE CYCLE; CHROMATIN; RATS; FLUORESCENCE; AMINO ACID SEQUENCE; IN-SITU HYBRIDIZATION; POLYMERASE CHAIN REACTION; NUCLEOTIDES

Citation Formats

Meuwissen, R L.J., Meerts, I, and Heyting, C. Human synaptonemal complex protein 1 (SCP1): Isolation and characterization of the cDNA and chromosomal localization of the gene. United States: N. p., 1997. Web. doi:10.1006/geno.1996.4373.
Meuwissen, R L.J., Meerts, I, & Heyting, C. Human synaptonemal complex protein 1 (SCP1): Isolation and characterization of the cDNA and chromosomal localization of the gene. United States. https://doi.org/10.1006/geno.1996.4373
Meuwissen, R L.J., Meerts, I, and Heyting, C. 1997. "Human synaptonemal complex protein 1 (SCP1): Isolation and characterization of the cDNA and chromosomal localization of the gene". United States. https://doi.org/10.1006/geno.1996.4373.
@article{osti_476889,
title = {Human synaptonemal complex protein 1 (SCP1): Isolation and characterization of the cDNA and chromosomal localization of the gene},
author = {Meuwissen, R L.J. and Meerts, I and Heyting, C},
abstractNote = {Synaptonemal complexes (SCs) are structures that are formed between homologous chromosomes (homologs) during meiotic prophase. They consist of two proteinaceous axes, one along each homolog, that are connected along their length by numerous transverse filaments (TFs). The cDNA encoding one major component of TFs of SCs of the rat, rnSCP1, has recently been isolated and characterized. In this paper we describe the isolation and characterization of the cDNA encoding the human protein homologous to rnSCP1, hsSCP1. hsSCP1 and rnSCP1 have 75% amino acid identity. The most prominent structural features and amino acid sequence motifs of rnSCP1 have been conserved in hsSCP1. Most probably, hsSCP1 is functionally homologous to rnSCP1. The hsSCP1 gene was assigned to human chromosome 1p12-p13 by fluorescence in situ hybridization. 44 refs., 4 figs.},
doi = {10.1006/geno.1996.4373},
url = {https://www.osti.gov/biblio/476889}, journal = {Genomics},
number = 3,
volume = 39,
place = {United States},
year = {Sat Feb 01 00:00:00 EST 1997},
month = {Sat Feb 01 00:00:00 EST 1997}
}