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Title: Benzene-induced chromosome aberrations: A follow-up study

To study the evolution of cytogenetic damage from past exposure to high concentrations of benzene and its health significance, chromosome aberrations (CA) in lymphocytes were reinvestigated after approximately 20 years in four subjects with past severe hemopathy and in seven controls studied in the late 1960s. Increased chromosome-type aberrations were still present up to 30 years after benzene toxicity, but blood counts were normal. The vital status at the end of 1993 was ascertained for 32 subjects with a history of benzene toxicity and for 31 controls studied for CA from 1965 to 1970, who differed significantly for CA rates. Of the 32 benzene-exposed subjects, 1 was lost to follow-up, 20 were still alive, and 11 had died at ages 36 to 83, between 1 and 20 years after the last CA study. Five deaths were from neoplasia (acute erythroleukemia, brain tumor, cancer of lung, paranasal cavity, esophagus). The deceased subjects had significantly higher rates of chromosome-type aberrations than those alive, and those who died of neoplasia had the highest rates of these aberrations in the last study before death or diagnosis of cancer. Out of the 31 controls, 12 had died from 4 to 23 years after the CAmore » study. Three deaths were from neoplasia (two lung cancer, one brain tumor). Even if this is a small sample, the results suggest a higher risk of cancer for the benzene-exposed cohort, who had persistently high CA rates in lymphocytes. 10 refs., 4 tabs.« less
Authors:
 [1]
  1. Univ. of Milan (Italy)
Publication Date:
OSTI Identifier:
472177
Report Number(s):
CONF-9506288--
Journal ID: EVHPAZ; ISSN 0091-6765; TRN: 97:001626-0029
Resource Type:
Journal Article
Resource Relation:
Journal Name: Environmental Health Perspectives; Journal Volume: 104; Journal Issue: Suppl.6; Conference: Benzene `95: international conference on benzene toxicity, carcinogenesis, and epidemiology, Piscataway, NJ (United States), 17-20 Jun 1995; Other Information: PBD: Dec 1996
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
02 PETROLEUM; 55 BIOLOGY AND MEDICINE, BASIC STUDIES; BENZENE; BIOLOGICAL EFFECTS; LYMPHOCYTES; CHROMOSOMAL ABERRATIONS; TOXICITY; BIOLOGICAL INDICATORS; OCCUPATIONAL EXPOSURE; EXHAUST GASES; AIR POLLUTION; PETROLEUM REFINERIES; CARCINOGENS