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Title: Localization of a gene for a glutamate binding subunit of a NMDA receptor (GRINA) to 8q24

This article reports on the localization of a gene for a glutamate binding subunit of an N-methyl-D-aspartate (NMDA) receptor, called GRINA, to human chromosome 8q24 using fluorescence in situ hybridization and radiation hybridization mapping. This gene mapped outside the critical region for benign familial neonatal convulsions (BFNC), a rare form of epilepsy; however, GRINA could be the causative genetic factor inducing idiopathic generalized epilepsy. Further studies need to be conducted. 15 refs., 2 figs.
Authors:
; ;  [1]
  1. Univ. of Texas Health Science Center, San Antonio, TX (United States) [and others
Publication Date:
OSTI Identifier:
466407
Resource Type:
Journal Article
Resource Relation:
Journal Name: Genomics; Journal Volume: 32; Journal Issue: 1; Other Information: PBD: 15 Feb 1996
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; GENES; DNA-CLONING; GENETIC MAPPING; DNA SEQUENCING; MUTATION FREQUENCY; GENE MUTATIONS; R CODES; RESOLUTION; HUMAN CHROMOSOME 8; EPILEPSY; PATHOGENESIS; NEONATES; HEREDITARY DISEASES; FLUORESCENCE; DNA HYBRIDIZATION; NUCLEOTIDES; RADIATION INDUCED MUTANTS; TELOMERES; BIOLOGICAL MARKERS; DOMINANT MUTATIONS; PROBES; POLYMERASE CHAIN REACTION