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Title: DNA polymerase having modified nucleotide binding site for DNA sequencing

A modified gene encoding a modified DNA polymerase is disclosed. The modified polymerase incorporates dideoxynucleotides at least 20-fold better compared to the corresponding deoxynucleotides as compared with the corresponding naturally-occurring DNA polymerase. 6 figs.
Authors:
;
Publication Date:
OSTI Identifier:
458581
Report Number(s):
US 5,614,365/A/
PAN: US patent application 8-337,615
DOE Contract Number:
FG02-88ER60688
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 25 Mar 1997
Research Org:
Harvard University
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; DNA POLYMERASES; GENES; DNA SEQUENCING; RECEPTORS; NUCLEOTIDES; POLYMERASE CHAIN REACTION; BIOTECHNOLOGY