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Title: Immunotherapy of metastatic melanoma by reversal of immune suppression

Beginning with the observation that the human enteorvirus, Poliovirus Sabin 1, will lyse human melanoma cells in culture, clinical trials involving two patients with advance melanoma were performed. Parenteral injection of the viable Poliovirus into cutaneous melanoma metastases followed in 24 hours by oral administration of cyclophosphamide. The results of these two trials are described.
Authors:
;
Publication Date:
OSTI Identifier:
454026
Report Number(s):
UCRL-ID--125830
ON: DE97051512
DOE Contract Number:
W-7405-ENG-48
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: Jan 1997
Research Org:
Lawrence Livermore National Lab., CA (United States)
Sponsoring Org:
USDOE, Washington, DC (United States)
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; MELANOMAS; IMMUNOTHERAPY; LYMPHOCYTES; CELL KILLING; VIRUSES; PATIENTS