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Title: Systematic screening for mutations in the human serotonin 1F receptor gene in patients with bipolar affective disorder and schizophrenia

Using single strand conformational analysis we screened the complete coding sequence of the serotonin 1F (5-HT{sub 1F}) receptor gene for the presence of DNA sequence variation in a sample of 137 unrelated individuals including 45 schizophrenic patients, 46 bipolar patients, as well as 46 healthy controls. We detected only three rare sequence variants which are characterized by single base pair substitutions, namely a silent T{r_arrow}A transversion in the third position of codon 261 (encoding isoleucine), a silent C{r_arrow}T transition in the third position of codon 176 (encoding histidine), and a C{r_arrow}T transition in position -78 upstream from the start codon. The lack of significant mutations in patients suffering from schizophrenia and bipolar affective disorder indicates that the 5-HT{sub 1F} receptor is not commonly involved in the etiology of these diseases. 12 refs., 1 fig., 2 tabs.
Authors:
; ; ; ;  [1]
  1. Univ. of Bonn (Germany) [and others
Publication Date:
OSTI Identifier:
447666
Resource Type:
Journal Article
Resource Relation:
Journal Name: American Journal of Medical Genetics; Journal Volume: 67; Journal Issue: 2; Other Information: PBD: 9 Apr 1996
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; NERVOUS SYSTEM DISEASES; ETIOLOGY; PATIENTS; MENTAL DISORDERS; HEREDITARY DISEASES; SEROTONIN; RECEPTORS; GENETIC MAPPING; GENE MUTATIONS; DNA SEQUENCING; SCREENING; NUCLEOTIDES; POLYMERASE CHAIN REACTION