Search for a gene predisposing to manic-depression on chromosome 21

Journal Article · Mon Jun 19 00:00:00 EDT 1995 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320600312· OSTI ID:443846

Byerley, W; Holik, J; Hoff, M; Coon, H ^[1]

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1. Univ. of Utah Medical Center, Salt Lake City, UT (United States)

Six kindreds containing multiple cases of manic-depressive illness (MDI) were genotyped with seven highly polymorphic microsatellite loci used in the construction of an index map for chromosome 21. The kindreds were also genotyped with a microsatellite polymorphism for PFKL, a chromosome 21 locus that has shown suggestive linkage to MDI in one pedigree. Evidence of linkage was not found assuming either autosomal dominant or recessive inheritance. The nonparametric affected sib pair test did not yield significant evidence of linkage. 11 refs., 1 fig., 3 tabs.

• Sponsoring Organization: USDOE
• OSTI ID: 443846
• Journal Information: American Journal of Medical Genetics, Vol. 60, Issue 3; Other Information: PBD: 19 Jun 1995
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
HUMAN CHROMOSOME 21
GENETIC MAPPING
MENTAL DISORDERS
GENETICS
GENES
PATIENTS
BEHAVIOR
HEREDITARY DISEASES
PHENOTYPE
GENOTYPE
BIOLOGICAL MARKERS
STATISTICS