Exclusion of linkage between alcoholism and the MNS blood group region on chromosome 4q in multiplex families

Neiswanger, K; Kaplan, B; Hill, S Y

doi:10.1002/ajmg.1320600113

Title: Exclusion of linkage between alcoholism and the MNS blood group region on chromosome 4q in multiplex families

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Abstract

Polymorphic DNA markers on the long arm of chromosome 4 were used to examine linkage to alcoholism in 20 multiplex pedigrees. Fifteen loci were determined for 124 individuals. Lod scores were calculated assuming both dominant and recessive disease modes of inheritance, utilizing incidence data by age and gender that allow for correction for variable age of onset and frequency of the disorder by gender. Under the assumption that alcoholism is homogeneous in this set of pedigrees, and that a recessive mode with age and gender correction is the most appropriate, the total lod scores for all families combined were uniformly lower than -2.0. This suggests an absence of linkage between the putative alcoholism susceptibility gene and markers in the region of the MNS blood group (4q28-31), a region for which we had previously found suggestive evidence of linkage to alcoholism. The 100 cM span of chromosome 4 studied includes the class I alcohol dehydrogenase (ADH) loci. Using the recessive mode, no evidence for linkage to alcoholism was found for the markers tested, which spanned almost the entire long arm of chromosome 4. Under the dominant mode, no evidence for linkage could be found for several of the markers. 36 refs.,more » 1 fig., 3 tabs.« less

Authors:

Neiswanger, K; Kaplan, B; Hill, S Y ^[1]

Univ. of Pittsburgh School of Medicine, PA (United States)

Publication Date:: Mon Feb 27 00:00:00 EST 1995

Sponsoring Org.:: USDOE

OSTI Identifier:: 443800

Resource Type:: Journal Article

Journal Name:: American Journal of Medical Genetics

Additional Journal Information:: Journal Volume: 60; Journal Issue: 1; Other Information: PBD: 27 Feb 1995

Country of Publication:: United States

Language:: English

Subject:: 55 BIOLOGY AND MEDICINE, BASIC STUDIES; HUMAN CHROMOSOMES; GENETIC MAPPING; PATIENTS; HEREDITARY DISEASES; DRUG ABUSE; BLOOD GROUPS; GENETICS; AGE DEPENDENCE; SEX DEPENDENCE; GENES; BIOLOGICAL MARKERS; STATISTICS; ALCOHOL DEHYDROGENASE; RFLPS

Citation Formats


                    Neiswanger, K, Kaplan, B, and Hill, S Y. Exclusion of linkage between alcoholism and the MNS blood group region on chromosome 4q in multiplex families.  United States: N. p., 1995. 
        Web.  doi:10.1002/ajmg.1320600113.

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                    Neiswanger, K, Kaplan, B, & Hill, S Y. Exclusion of linkage between alcoholism and the MNS blood group region on chromosome 4q in multiplex families.  United States.  https://doi.org/10.1002/ajmg.1320600113

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                    Neiswanger, K, Kaplan, B, and Hill, S Y. 1995.  
        "Exclusion of linkage between alcoholism and the MNS blood group region on chromosome 4q in multiplex families".  United States.  https://doi.org/10.1002/ajmg.1320600113.

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@article{osti_443800,

  title        = {Exclusion of linkage between alcoholism and the MNS blood group region on chromosome 4q in multiplex families},

  author       = {Neiswanger, K and Kaplan, B and Hill, S Y},

  abstractNote = {Polymorphic DNA markers on the long arm of chromosome 4 were used to examine linkage to alcoholism in 20 multiplex pedigrees. Fifteen loci were determined for 124 individuals. Lod scores were calculated assuming both dominant and recessive disease modes of inheritance, utilizing incidence data by age and gender that allow for correction for variable age of onset and frequency of the disorder by gender. Under the assumption that alcoholism is homogeneous in this set of pedigrees, and that a recessive mode with age and gender correction is the most appropriate, the total lod scores for all families combined were uniformly lower than -2.0. This suggests an absence of linkage between the putative alcoholism susceptibility gene and markers in the region of the MNS blood group (4q28-31), a region for which we had previously found suggestive evidence of linkage to alcoholism. The 100 cM span of chromosome 4 studied includes the class I alcohol dehydrogenase (ADH) loci. Using the recessive mode, no evidence for linkage to alcoholism was found for the markers tested, which spanned almost the entire long arm of chromosome 4. Under the dominant mode, no evidence for linkage could be found for several of the markers. 36 refs., 1 fig., 3 tabs.},

  doi          = {10.1002/ajmg.1320600113},

  url          = {https://www.osti.gov/biblio/443800},
  journal      = {American Journal of Medical Genetics},
number       = 1,

  volume       = 60,

  place        = {United States},

  year         = {Mon Feb 27 00:00:00 EST 1995},

  month        = {Mon Feb 27 00:00:00 EST 1995}

}

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