Lack of significant association between spina bifida and the fragile X syndrome
- United Cerebral Palsy of Nassau County, Roosevelt, NY (United States)
- Albert Einstein College of Medicine, Bronx, NY (United States)
- Inst. for Basic Research, Staten Island, NY (United States)
Folic acid is involved in two common disorders associated with developmental disabilities. Spina bifida is a malformation that may be associated with mental retardation, learning disabilities, and epilepsy. Its incidence can be reduced by the ingestion of folic acid before, and at the time of, conception. The fragile X syndrome is a genetic disorder which is the most common form of inherited mental retardation. This disorder can be diagnosed by the induction of fragile sites on the X chromosome which is cultured in a medium deficient in folic acid. In several studies, folic acid was reported to alleviate some of the developmental and behavioral manifestations associated in the fragile X syndrome, while in others, it has no effect. 9 refs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 443771
- Journal Information:
- American Journal of Medical Genetics, Vol. 59, Issue 4; Other Information: PBD: 4 Dec 1995
- Country of Publication:
- United States
- Language:
- English
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