Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia

Journal Article · Fri Feb 16 00:00:00 EST 1996 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/(SICI)1096-8628(19960216)67:1<103::AID-AJMG18>3.0.CO;2-S· OSTI ID:437204

Inayama, Y; Yoneda, H; Sakai, T ^[1]

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1. Osaka Medical College (Japan); and others

Sixty-two patients with schizophrenia and 96 normal controls were investigated for genetic association with restriction fragment length polymorphisms (RFLPs) in the serotonin receptor genes. A positive association between the serotonin 2A receptor gene (HTR2A) and schizophrenia was found, but not between schizophrenia and the serotonin 1A receptor gene. The positive association we report here would suggest that the DNA region with susceptibility to schizophrenia lies in the HTR2A on the long arm of chromosome 13. 15 refs., 2 tabs.

• OSTI ID: 437204
• Journal Information: American Journal of Medical Genetics, Vol. 67, Issue 1; Other Information: PBD: 16 Feb 1996
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
PATIENTS
HEREDITARY DISEASES
MENTAL DISORDERS
NERVOUS SYSTEM DISEASES
HUMAN CHROMOSOME 13
GENETIC MAPPING
RECEPTORS
DNA SEQUENCING
GENE MUTATIONS
SEROTONIN
RFLPS
BIOLOGICAL MARKERS
POLYMERASE CHAIN REACTION