Assignment of the gene encoding human galanin receptor (GALNR) to 18q23 by in situ hybridization
- Women`s and Children`s Hospital, Adelaide (Australia)
- Garvan Institute of Medical Research, New South Wales (Australia); and others
The neuropeptide galanin is widely distributed throughout the central and peripheral nervous systems of mammalian, avian, reptilian, and fish species and has a broad range of physiological and behavioral effects. Human galanin is a 30-amino-acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the seven transmembrane family of G-protein-coupled receptors. A functional human galanin receptor has recently been cloned, and we report here the localization of the gene encoding this receptor (GALNR) to chromosome 18q23. 5 refs., 1 fig.
- OSTI ID:
- 437189
- Journal Information:
- Genomics, Vol. 30, Issue 3; Other Information: PBD: 10 Dec 1995
- Country of Publication:
- United States
- Language:
- English
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