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Title: Inhibition by progesterone of radiation-estrogen-induced mammary cancer in the rat

The data from this preliminary experiment make it appear that continuous administration of progesterone protects animals from the synergism between estrogen and radiation. However, it also appears that the progesterone has by itself a protective effect against the individual carcinogenic agents since fewer tumors occurred on the opposite side as well as on the radiated side. In this preliminary experiment none of the animals that bore just progesterone pellets and were radiated developed mammary carcinomata. (auth)
Authors:
Publication Date:
OSTI Identifier:
4365356
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cancer Res., v. 33, no. 5, pp. 1136-1137; Other Information: Orig. Receipt Date: 30-JUN-74
Research Org:
Alton Ochsner Medical Foundation, New Orleans
Country of Publication:
Country unknown/Code not available
Language:
English
Subject:
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates; *ESTROGENS-- CARCINOGENESIS; *NEOPLASMS-- RADIOINDUCTION; *PROGESTERONE-- RADIOSENSITIVITY EFFECTS; BIOLOGICAL RADIATION EFFECTS; IONIZING RADIATIONS; MAMMARY GLANDS; PARTIAL BODY IRRADIATION; RADIOSENSITIVITY EFFECTS; RATS; RESPONSE MODIFYING FACTORS; SYNERGISM RADIOINDUCTION