skip to main content

Title: Thyroid nodularity and cancer among Chernobyl cleanup workers from Estonia

Thyroid examinations, including palpation, ultrasound and, selectively, fine-needle aspiration biopsy, were conducted on nearly 2,000 Chernobyl cleanup workers from Estonia to evaluate the occurrence of thyroid cancer and nodular thyroid disease among men with protracted exposure to ionizing radiation. The examinations were conducted in four cities in Estonia during March-April 1995, 9 years after the reactor accident. The study population was selected from a predefined cohort of 4,833 cleanup workers from Estonia under surveillance for cancer incidence. These men had been sent to Chernobyl between 1986 and 1991 to entomb the damaged reactor, remove radioactive debris and perform related cleanup activities. A total of 2,997 men were invited for thyroid screening and 1,984 (66%) were examined. Estimates of radiation dose from external sources were obtained from military or other institutional records, and details about service dates and types of work performed while at Chernobyl were obtained from a self-administered questionnaire. Blood samples were collected for assay of chromosomal translocations in circulating lymphocytes and loss of expression of the glycophorin A (GPA) gene in erythrocytes. The primary outcome measure was the presence or absence of thyroid nodules as determined by the ultrasound examination. Of the screened workers, 1,247 (63%) were sentmore » to Chernobyl in 1986, including 603 (30%) sent in April or May, soon after the accident. Workers served at Chernobyl for an average of 3 months. The average age was 32 years at the time of arrival at Chernobyl and 40 years at the time of thyroid examination. The mean documented radiation dose from external sources was 10.8 cGy. Biological indicators of exposure showed low correlations with documented dose, but did not indicate that the mean dose for the population was higher than the average documented dose. 47 refs., 1 fig., 9 tabs.« less
Authors:
;  [1] ;  [2]
  1. National Cancer Inst., Rockville, MD (United States)
  2. Univ. of New Mexico, Albuquerque, NM (United States) [and others
Publication Date:
OSTI Identifier:
433066
DOE Contract Number:
W-7405-ENG-48
Resource Type:
Journal Article
Resource Relation:
Journal Name: Radiation Research; Journal Volume: 147; Journal Issue: 2; Other Information: PBD: Feb 1997
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; CHERNOBYLSK-4 REACTOR; DECONTAMINATION; THYROID; NEOPLASMS; MEN; BIOLOGICAL RADIATION EFFECTS; PERSONNEL; OCCUPATIONAL EXPOSURE; REMEDIAL ACTION; BIOLOGICAL INDICATORS; BIOPSY; BLOOD; ERYTHROCYTES; ESTONIA; LYMPHOCYTES; RADIATION DOSES