Linkage analysis of chromosome 22q12-13 in a United Kingdom/Icelandic sample of 23 multiplex schizophrenia families
Journal Article
·
· American Journal of Medical Genetics
- Univ. College London Medical School (United Kingdom); and others
A possible linkage to a genetic subtype of schizophrenia and related disorders has been reported on the long arm of chromosome 22 at q12-13. However formal statistical tests in a combined sample could not reject homogeneity and prove that there was linked subgroup of families. We have studied 23 schizophrenia pedigrees to test whether some multiplex schizophrenia families may be linked to the microsatellite markers D22S274 and D22S283 which span the 22q12-13 region. Two point followed by multipoint lod and non-parametric linkage analyses under the assumption of heterogeneity provided no evidence for linkage over the relevant region. 16 refs., 4 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 426173
- Journal Information:
- American Journal of Medical Genetics, Vol. 60, Issue 4; Other Information: PBD: 14 Aug 1995
- Country of Publication:
- United States
- Language:
- English
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