Elevated incidence of childhood leukemia in Woburn, Massachusetts: NIEHS Superfund Basic Research Program searches for causes

Durant, J L; Chen, J; Hemond, H F; Thilly, W G

doi:10.1289/ehp.95103s693

Title: Elevated incidence of childhood leukemia in Woburn, Massachusetts: NIEHS Superfund Basic Research Program searches for causes

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Abstract

Between 1966 and 1986, the childhood leukemia rate in Woburn, Massachusetts, was 4-fold higher than the national average. A multidisciplinary research team from MIT, which is being supported by the NIEHS Superfund Basic Research Program, has explored the possible importance of a temporal correlation between the period of elevated leukemia and a previously unrecognized mobilization of toxic metals from a waste disposal site in north Woburn. Residents of Woburn may have been exposed to arsenic (70 {mu}g/l) and chromium (240 {mu}g/l) at levels in excess of federal drinking water standards (50 {mu}g/l for each metal) by consuming municipal groundwater contaminated with these metals. Research is currently underway (a) to elucidate the mechanisms and the pathways by which these metals were transported form the waste disposal site to the drinking water supply; (b) to determine the identity of the principal human cell mutagens in samples of aquifer materials collected form the site of the municipal supply wells; and (c) to measure the extent of exposure and genetic change in residents who consumed the contaminated well water. 11 refs., 11 figs., 1 tab.

Authors:

Durant, J L; Chen, J; Hemond, H F; Thilly, W G ^[1]

Massachusetts Inst. of Technology, Cambridge, MA (United States)

Publication Date:: Fri Sep 01 00:00:00 EDT 1995

Sponsoring Org.:: USDOE

OSTI Identifier:: 426041

Resource Type:: Journal Article

Journal Name:: Environmental Health Perspectives

Additional Journal Information:: Journal Volume: 103; Journal Issue: Suppl.6; Other Information: PBD: Sep 1995

Country of Publication:: United States

Language:: English

Subject:: 56 BIOLOGY AND MEDICINE, APPLIED STUDIES; HAZARDOUS MATERIALS; BIOLOGICAL EFFECTS; ENVIRONMENTAL EXPOSURE; CHROMIUM; CHILDREN; LEUKEMIA; US SUPERFUND

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                    Durant, J L, Chen, J, Hemond, H F, and Thilly, W G. Elevated incidence of childhood leukemia in Woburn, Massachusetts: NIEHS Superfund Basic Research Program searches for causes.  United States: N. p., 1995. 
        Web.  doi:10.1289/ehp.95103s693.

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                    Durant, J L, Chen, J, Hemond, H F, & Thilly, W G. Elevated incidence of childhood leukemia in Woburn, Massachusetts: NIEHS Superfund Basic Research Program searches for causes.  United States.  https://doi.org/10.1289/ehp.95103s693

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                    Durant, J L, Chen, J, Hemond, H F, and Thilly, W G. 1995.  
        "Elevated incidence of childhood leukemia in Woburn, Massachusetts: NIEHS Superfund Basic Research Program searches for causes".  United States.  https://doi.org/10.1289/ehp.95103s693.

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@article{osti_426041,

  title        = {Elevated incidence of childhood leukemia in Woburn, Massachusetts: NIEHS Superfund Basic Research Program searches for causes},

  author       = {Durant, J L and Chen, J and Hemond, H F and Thilly, W G},

  abstractNote = {Between 1966 and 1986, the childhood leukemia rate in Woburn, Massachusetts, was 4-fold higher than the national average. A multidisciplinary research team from MIT, which is being supported by the NIEHS Superfund Basic Research Program, has explored the possible importance of a temporal correlation between the period of elevated leukemia and a previously unrecognized mobilization of toxic metals from a waste disposal site in north Woburn. Residents of Woburn may have been exposed to arsenic (70 {mu}g/l) and chromium (240 {mu}g/l) at levels in excess of federal drinking water standards (50 {mu}g/l for each metal) by consuming municipal groundwater contaminated with these metals. Research is currently underway (a) to elucidate the mechanisms and the pathways by which these metals were transported form the waste disposal site to the drinking water supply; (b) to determine the identity of the principal human cell mutagens in samples of aquifer materials collected form the site of the municipal supply wells; and (c) to measure the extent of exposure and genetic change in residents who consumed the contaminated well water. 11 refs., 11 figs., 1 tab.},

  doi          = {10.1289/ehp.95103s693},

  url          = {https://www.osti.gov/biblio/426041},
  journal      = {Environmental Health Perspectives},
number       = Suppl.6,

  volume       = 103,

  place        = {United States},

  year         = {Fri Sep 01 00:00:00 EDT 1995},

  month        = {Fri Sep 01 00:00:00 EDT 1995}

}

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