The mononuclear molybdenum enzymes
- Ohio State Univ., Columbus, OH (United States). Dept. of Medical Biochemistry
Molybdenum is widely available to biological systems due to the solubility of its high-valent oxides in water and is found in two basic forms: as an integral component of the multinuclear M center of nitrogenases and as the mononuclear active sites of a much more diverse group of enzymes that in general function catalytically to transfer an oxygen atom either to or from a physiological acceptor/donor molecule. It is on the basis of this commonly encountered aspect of catalysis that these enzymes are frequently referred to as oxotransferases, although no mechanistic connotation is intended in using the term. Similarly, the vast majority of these enzymes possess a Mo{double_bond}O unit in their active sites and are often referred to as oxomolybdenum enzymes. Neither of these terms is strictly applicable to the entire class of enzymes, however, as some (polysulfide reductase, for example, and possibly formate dehydrogenase) do not possess a Mo{double_bond}O unit. Here the term mononuclear molybdenum enzymes will be used in order to be as generic as possible. 431 refs.
- Sponsoring Organization:
- National Insts. of Health, Bethesda, MD (United States); National Science Foundation, Washington, DC (United States)
- OSTI ID:
- 415592
- Journal Information:
- Chemical Reviews, Vol. 96, Issue 7; Other Information: PBD: Nov 1996
- Country of Publication:
- United States
- Language:
- English
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