Statistical Mechanics of Prion Diseases
Journal Article
·
· Physical Review Letters
We present a two-dimensional, lattice based, protein-level statistical mechanical model for prion diseases (e.g., mad cow disease) with concomitant prion protein misfolding and aggregation. Our studies lead us to the hypothesis that the observed broad incubation time distribution in epidemiological data reflect fluctuation dominated growth seeded by a few nanometer scale aggregates, while much narrower incubation time distributions for innoculated lab animals arise from statistical self-averaging. We model ''species barriers'' to prion infection and assess a related treatment protocol.
- Sponsoring Organization:
- (US)
- OSTI ID:
- 40277303
- Journal Information:
- Physical Review Letters, Vol. 87, Issue 5; Other Information: DOI: 10.1103/PhysRevLett.87.058101; Othernumber: PRLTAO000087000005058101000001; 011131PRL; PBD: 30 Jul 2001; ISSN 0031-9007
- Publisher:
- The American Physical Society
- Country of Publication:
- United States
- Language:
- English
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