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Title: Estimates of intakes and internal doses from ingestion of {sup 32}P at MIT and NIH

Abstract

A researcher at Massachusetts Institute of Technology (MIT) became internally contaminated with {sup 32}P, probably due to an intentional act. The incident occurred on or about 14 August 1995. Subsequent measurement of activity in urine and a single whole body count were used to estimate the individual`s intake, with the assumption of ingestion as the route of intake. Two separate Sets of urine data were analyzed-one supplied by MIT and one from independent analyses of urine samples conducted at Oak Ridge Institute for Science and Education (ORISE); the former data set contained 35 samples, the latter 49. In addition, the results of 35 whole body counts, provided by MIT from a chair-type counter calibrated for 32p, were used to obtain a separate estimate of intake. The kinetic model for 32P proposed in ICRP Publication 30 and implemented in NUREG/CR-4884 was used to interpret the data. The data were analyzed using both the weighted and unweighted least squares techniques. All of the intake estimates were in very good agreement with each other, ranging from 18-22 MBq. Based on the dose model in ICRP 30, this would indicate a committed effective dose equivalent of 38-46 mSv. The incident was helpful in assessingmore » the value of the least squares techniques in determining estimates of intake and dose. The ICRP model tended to slightly overestimate the whole body retention data and underestimate the urinary excretion at later times. Further results obtained by visual best fit and development of an individual-specific kinetic and dose model will also be discussed. This incident was quite similar to another case of ingestion of 32p that occurred at the National Institute of Health (NIH) on 28 June 1995. Dose assessment for the NIH case will also be presented if the data are available for public release.« less

Authors:
;  [1]
  1. Oak Ridge Inst. for Science and Education, TN (United States)
Publication Date:
OSTI Identifier:
393944
Report Number(s):
CONF-9607135-
Journal ID: HLTPAO; ISSN 0017-9078; TRN: 96:028626
Resource Type:
Journal Article
Journal Name:
Health Physics
Additional Journal Information:
Journal Volume: 70; Journal Issue: Suppl.6; Conference: 41. Annual Meeting of the Health Physics Society, Seattle, WA (United States), 21-25 Jul 1996; Other Information: PBD: Jun 1996
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; PHOSPHORUS 32; INGESTION; RADIATION DOSES; OCCUPATIONAL EXPOSURE; EXCRETION; ICRP; RETENTION; URINE; DOSE EQUIVALENTS; WHOLE-BODY COUNTING

Citation Formats

Stabin, M G, and Toohey, R E. Estimates of intakes and internal doses from ingestion of {sup 32}P at MIT and NIH. United States: N. p., 1996. Web.
Stabin, M G, & Toohey, R E. Estimates of intakes and internal doses from ingestion of {sup 32}P at MIT and NIH. United States.
Stabin, M G, and Toohey, R E. 1996. "Estimates of intakes and internal doses from ingestion of {sup 32}P at MIT and NIH". United States.
@article{osti_393944,
title = {Estimates of intakes and internal doses from ingestion of {sup 32}P at MIT and NIH},
author = {Stabin, M G and Toohey, R E},
abstractNote = {A researcher at Massachusetts Institute of Technology (MIT) became internally contaminated with {sup 32}P, probably due to an intentional act. The incident occurred on or about 14 August 1995. Subsequent measurement of activity in urine and a single whole body count were used to estimate the individual`s intake, with the assumption of ingestion as the route of intake. Two separate Sets of urine data were analyzed-one supplied by MIT and one from independent analyses of urine samples conducted at Oak Ridge Institute for Science and Education (ORISE); the former data set contained 35 samples, the latter 49. In addition, the results of 35 whole body counts, provided by MIT from a chair-type counter calibrated for 32p, were used to obtain a separate estimate of intake. The kinetic model for 32P proposed in ICRP Publication 30 and implemented in NUREG/CR-4884 was used to interpret the data. The data were analyzed using both the weighted and unweighted least squares techniques. All of the intake estimates were in very good agreement with each other, ranging from 18-22 MBq. Based on the dose model in ICRP 30, this would indicate a committed effective dose equivalent of 38-46 mSv. The incident was helpful in assessing the value of the least squares techniques in determining estimates of intake and dose. The ICRP model tended to slightly overestimate the whole body retention data and underestimate the urinary excretion at later times. Further results obtained by visual best fit and development of an individual-specific kinetic and dose model will also be discussed. This incident was quite similar to another case of ingestion of 32p that occurred at the National Institute of Health (NIH) on 28 June 1995. Dose assessment for the NIH case will also be presented if the data are available for public release.},
doi = {},
url = {https://www.osti.gov/biblio/393944}, journal = {Health Physics},
number = Suppl.6,
volume = 70,
place = {United States},
year = {Sat Jun 01 00:00:00 EDT 1996},
month = {Sat Jun 01 00:00:00 EDT 1996}
}