Effect of chronic copper and pentachlorophenol exposure to early life stages of Xenopus laevis
Abstract
An evaluation of the effects of low-level copper and pentachlorophenol exposure on various early life stages of the South African clawed frog, Xenopus laevis was performed using stage-specific and long-term continuous exposures. Stage-specific exposure experiments were conducted such that separate subsets of embryos and larvae from the same clutch were exposed to two toxicants, copper and pentachlorophenol, from 0 d to 4 d (standard Frog Embryo Teratagenesis Assay Xenopus [FETAX]), 4 d to 8 d, 8 d to 12 d, and 12 d to 16 d. Results from two separate concentration-response experiments indicated that sensitivity to either toxicant increased in each successive time period. Continuous exposure studies conducted for 60 to 75 days indicated that copper, but not pentachlorophenol induced reduction deficiency malformations of the hind limb at concentrations as low as 0.05 mg/L. Pentachlorophenol concentrations as low as 0.5/{micro}g/L inhibited tail resorption. However, copper did not adversely affect the process of tail resorption. These results indicated that studies evaluating longer-term developmental processes are important in ecological hazard evaluation.
- Authors:
-
- Stover Group, Stillwater, OK (United States)
- Publication Date:
- OSTI Identifier:
- 392355
- Report Number(s):
- CONF-9511137-
ISBN 1-880611-03-1; TRN: IM9647%%209
- Resource Type:
- Conference
- Resource Relation:
- Conference: 2. Society of Environmental Toxicology and Chemistry (SETAC) world conference, Vancouver (Canada), 5-9 Nov 1995; Other Information: PBD: 1995; Related Information: Is Part Of Second SETAC world congress (16. annual meeting): Abstract book. Global environmental protection: Science, politics, and common sense; PB: 378 p.
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 56 BIOLOGY AND MEDICINE, APPLIED STUDIES; COPPER; TERATOGEN SCREENING; CHLORINATED AROMATIC HYDROCARBONS; FROGS; BIOLOGICAL STRESS; DOSE-RESPONSE RELATIONSHIPS; CONGENITAL MALFORMATIONS
Citation Formats
Fort, D J, and Stover, E L. Effect of chronic copper and pentachlorophenol exposure to early life stages of Xenopus laevis. United States: N. p., 1995.
Web.
Fort, D J, & Stover, E L. Effect of chronic copper and pentachlorophenol exposure to early life stages of Xenopus laevis. United States.
Fort, D J, and Stover, E L. 1995.
"Effect of chronic copper and pentachlorophenol exposure to early life stages of Xenopus laevis". United States.
@article{osti_392355,
title = {Effect of chronic copper and pentachlorophenol exposure to early life stages of Xenopus laevis},
author = {Fort, D J and Stover, E L},
abstractNote = {An evaluation of the effects of low-level copper and pentachlorophenol exposure on various early life stages of the South African clawed frog, Xenopus laevis was performed using stage-specific and long-term continuous exposures. Stage-specific exposure experiments were conducted such that separate subsets of embryos and larvae from the same clutch were exposed to two toxicants, copper and pentachlorophenol, from 0 d to 4 d (standard Frog Embryo Teratagenesis Assay Xenopus [FETAX]), 4 d to 8 d, 8 d to 12 d, and 12 d to 16 d. Results from two separate concentration-response experiments indicated that sensitivity to either toxicant increased in each successive time period. Continuous exposure studies conducted for 60 to 75 days indicated that copper, but not pentachlorophenol induced reduction deficiency malformations of the hind limb at concentrations as low as 0.05 mg/L. Pentachlorophenol concentrations as low as 0.5/{micro}g/L inhibited tail resorption. However, copper did not adversely affect the process of tail resorption. These results indicated that studies evaluating longer-term developmental processes are important in ecological hazard evaluation.},
doi = {},
url = {https://www.osti.gov/biblio/392355},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sun Dec 31 00:00:00 EST 1995},
month = {Sun Dec 31 00:00:00 EST 1995}
}