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Title: Human 60-kDa SS-A/Ro ribonucleoprotein autoantigen gene (SSA2) localized to 1q31 by fluorescence in situ hybridization

Human autoantibodies to intracellular antigens are often found in patients with systemic rheumatic diseases. Our laboratory and others have reported the cloning of the cDNAs for two protein autoantigens. The 60-kDa protein is a member of the RNA binding protein family containing an RNA binding motif and has been shown to be primarily responsible for direct interaction with hY-RNAs. The assignment of the 60-kDa autoantigen gene (SSA2) to 1q31 may allow further investigation of the genetic basis of human autoimmune diseases in which ss-A/Ro antibodies are observed. 14 refs., 1 fig.
Authors:
;  [1] ;  [2]
  1. Scripps Research Institute, La Jolla, CA (United States)
  2. Yale Univ. School of Medicine, New Haven, CT (United States) [and others
Publication Date:
OSTI Identifier:
391789
Resource Type:
Journal Article
Resource Relation:
Journal Name: Genomics; Journal Volume: 23; Journal Issue: 1; Other Information: PBD: 1 Sep 1994
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; GENES; GENETIC MAPPING; DNA-CLONING; NUCLEOPROTEINS; HUMAN CHROMOSOME 1; RHEUMATIC DISEASES; DIAGNOSIS; DNA HYBRIDIZATION; FLUORESCENCE; ANTIGENS; PATIENTS; BIOLOGICAL MARKERS; RNA