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Title: Age and family relationship accentuate the risk of insulin-dependent diabetes mellitus (IDDM) in relatives of patients with IDDM

Abstract

The international community of diabetologists is rapidly becomine involved in intervention trials aimed at preventing insulin-dependent diabetes in high risk relatives. Whereas age and relationship to a proband with insulin-dependent diabetes mellitus interacting with detected islet cell autoantibodies (ICA) are risk factors, their independent contribution to that risk remains unclear. In a prospective study of 6851 nondiabetic relatives of 2742 probands conducted between 1979-1993, we found age, but not relationship, to be a dramatic risk variable in ICA-positive persons as estimated by the Cox regression model. The 5-yr risk of insulin-dependent diabetes mellitus was 66% for those found to have ICA detectable before age 10 yr, falling progressively to less than 16% for ICA-positive relatives over age 40 yr. In ICA-negative relatives, age and relationship are independent prognostic variables. 15 refs., 4 figs., 2 tabs.

Authors:
; ;  [1]
  1. Univ. of South Florida, Tampa, FL (United States); and others
Publication Date:
OSTI Identifier:
391045
Resource Type:
Journal Article
Journal Name:
Journal of Clinical Endocrinology and Metabolism
Additional Journal Information:
Journal Volume: 80; Journal Issue: 12; Other Information: PBD: Dec 1995
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; PATIENTS; HEREDITARY DISEASES; DIABETES MELLITUS; RISK ASSESSMENT; STATISTICAL MODELS; AGE DEPENDENCE; GENETICS; INSULIN

Citation Formats

Cantor, A B, Krischer, J P, and Cuthbertson, D D. Age and family relationship accentuate the risk of insulin-dependent diabetes mellitus (IDDM) in relatives of patients with IDDM. United States: N. p., 1995. Web. doi:10.1210/jc.80.12.3739.
Cantor, A B, Krischer, J P, & Cuthbertson, D D. Age and family relationship accentuate the risk of insulin-dependent diabetes mellitus (IDDM) in relatives of patients with IDDM. United States. https://doi.org/10.1210/jc.80.12.3739
Cantor, A B, Krischer, J P, and Cuthbertson, D D. 1995. "Age and family relationship accentuate the risk of insulin-dependent diabetes mellitus (IDDM) in relatives of patients with IDDM". United States. https://doi.org/10.1210/jc.80.12.3739.
@article{osti_391045,
title = {Age and family relationship accentuate the risk of insulin-dependent diabetes mellitus (IDDM) in relatives of patients with IDDM},
author = {Cantor, A B and Krischer, J P and Cuthbertson, D D},
abstractNote = {The international community of diabetologists is rapidly becomine involved in intervention trials aimed at preventing insulin-dependent diabetes in high risk relatives. Whereas age and relationship to a proband with insulin-dependent diabetes mellitus interacting with detected islet cell autoantibodies (ICA) are risk factors, their independent contribution to that risk remains unclear. In a prospective study of 6851 nondiabetic relatives of 2742 probands conducted between 1979-1993, we found age, but not relationship, to be a dramatic risk variable in ICA-positive persons as estimated by the Cox regression model. The 5-yr risk of insulin-dependent diabetes mellitus was 66% for those found to have ICA detectable before age 10 yr, falling progressively to less than 16% for ICA-positive relatives over age 40 yr. In ICA-negative relatives, age and relationship are independent prognostic variables. 15 refs., 4 figs., 2 tabs.},
doi = {10.1210/jc.80.12.3739},
url = {https://www.osti.gov/biblio/391045}, journal = {Journal of Clinical Endocrinology and Metabolism},
number = 12,
volume = 80,
place = {United States},
year = {Fri Dec 01 00:00:00 EST 1995},
month = {Fri Dec 01 00:00:00 EST 1995}
}