Murine chromosomal location of five bHLH-Zip transcription factor genes
- Univ. of Texas, Houston, TX (United States); and others
The genes for the bHLH-Zip transcription factors Tfap4, Mxi1, Tcfeb, Usf1, and Usf2 have been mapped in mouse by interspecific backcross analysis. Mxi1, Usf1, and Usf2 have been mapped previously by in situ hybridization, but their positions on the meiotic linkage map had not been determined. The other two genes have not previously been mapped in mouse. These transcription factors belong to a growing family of transcriptional regulators, some of which are known to form a complex network of interacting proteins that control cell proliferation and apoptosis. As expected, based on mapping studies of other bHLH-Zip genes, these loci were well distributed among mouse chromosomes. In addition, some of the probes used in this study detected multiple, independently segregating loci, suggesting the possible existence of additional family members or species-specific pseudogenes. 34 refs., 1 fig., 1 tab.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 390919
- Journal Information:
- Genomics, Vol. 28, Issue 2; Other Information: PBD: 20 Jul 1995
- Country of Publication:
- United States
- Language:
- English
Similar Records
Murine chromosomal location of eight members of the hepatocyte nuclear factor 3/fork head winged helix family of transcription factors
The murine homeobox genes Nkx2.3 and Nkx2.6 are located on chromosomes 19 and 14, respectively