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Title: The influence of sex on life shortening and tumor induction in CBA/Cne mice exposed to x rays or fission neutrons

Abstract

An experimental study of male and female CBA/Cne mice was set up at Casaccia primarily to investigate the influence of sex on long-term survival and tumor induction after exposure to high- and low-LET radiation. Mice were whole-body-irradiated at 3 months of age with fission-neutron doses of 0.1, 0.2, 0.4, 0.8, 1.2 and 1.8 Gy at the RSV-TAPIRO reactor (mean neutron energy 0.4 MeV, in terms of kerma, y{sub D} = 51.5 KeV/{mu}m), or with 250 KVp X-ray doses of 1, 3, 5 and 7 Gy. Control and irradiated animals were then followed for their entire life span. As a general finding, male CBA/Cne mice appear more susceptible to tumori-genesis than females. In particular, the incidences of induced acute myeloid leukemia and malignant lymphomas are significant only in male mice. Benign and malignant solid tumors of many types are observed in mice of both sexes, the most frequent being in the lung, liver and ovary. However, evidence for a radiation response is limited to the case of Harderian gland neoplasms. In addition, a comparison of the observed frequency of all irradiated compared to unirradiated animals bearing solid tumors shows that the total tumor occurrence is not altered markedly by radiation exposure.more » A decrease in survival time is observed for both sexes and radiation types and correlates well with increasing dose. Moreover, both sex and radiation quality appear to influence the life shortening. A similar dose dependence of survival time is found when tumor-free animals alone are considered, suggesting a non-specific component of life-shortening. 18 refs., 3 figs., 5 tabs.« less

Authors:
; ; ;  [1]
  1. ENEA, CR-Casaccia, Rome (Italy); and others
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
381035
Resource Type:
Journal Article
Journal Name:
Radiation Research
Additional Journal Information:
Journal Volume: 146; Journal Issue: 1; Other Information: PBD: Jul 1996
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; MICE; NEOPLASMS; RADIOINDUCTION; FISSION NEUTRONS; LET; LIFE SPAN; LIVER; LYMPHOMAS; MYELOID LEUKEMIA; SURVIVAL TIME; WHOLE-BODY IRRADIATION; DOSE-RESPONSE RELATIONSHIPS; SEX

Citation Formats

Di Majo, V, Coppola, M, Rebessi, S, and Saran, A. The influence of sex on life shortening and tumor induction in CBA/Cne mice exposed to x rays or fission neutrons. United States: N. p., 1996. Web. doi:10.2307/3579399.
Di Majo, V, Coppola, M, Rebessi, S, & Saran, A. The influence of sex on life shortening and tumor induction in CBA/Cne mice exposed to x rays or fission neutrons. United States. https://doi.org/10.2307/3579399
Di Majo, V, Coppola, M, Rebessi, S, and Saran, A. 1996. "The influence of sex on life shortening and tumor induction in CBA/Cne mice exposed to x rays or fission neutrons". United States. https://doi.org/10.2307/3579399.
@article{osti_381035,
title = {The influence of sex on life shortening and tumor induction in CBA/Cne mice exposed to x rays or fission neutrons},
author = {Di Majo, V and Coppola, M and Rebessi, S and Saran, A},
abstractNote = {An experimental study of male and female CBA/Cne mice was set up at Casaccia primarily to investigate the influence of sex on long-term survival and tumor induction after exposure to high- and low-LET radiation. Mice were whole-body-irradiated at 3 months of age with fission-neutron doses of 0.1, 0.2, 0.4, 0.8, 1.2 and 1.8 Gy at the RSV-TAPIRO reactor (mean neutron energy 0.4 MeV, in terms of kerma, y{sub D} = 51.5 KeV/{mu}m), or with 250 KVp X-ray doses of 1, 3, 5 and 7 Gy. Control and irradiated animals were then followed for their entire life span. As a general finding, male CBA/Cne mice appear more susceptible to tumori-genesis than females. In particular, the incidences of induced acute myeloid leukemia and malignant lymphomas are significant only in male mice. Benign and malignant solid tumors of many types are observed in mice of both sexes, the most frequent being in the lung, liver and ovary. However, evidence for a radiation response is limited to the case of Harderian gland neoplasms. In addition, a comparison of the observed frequency of all irradiated compared to unirradiated animals bearing solid tumors shows that the total tumor occurrence is not altered markedly by radiation exposure. A decrease in survival time is observed for both sexes and radiation types and correlates well with increasing dose. Moreover, both sex and radiation quality appear to influence the life shortening. A similar dose dependence of survival time is found when tumor-free animals alone are considered, suggesting a non-specific component of life-shortening. 18 refs., 3 figs., 5 tabs.},
doi = {10.2307/3579399},
url = {https://www.osti.gov/biblio/381035}, journal = {Radiation Research},
number = 1,
volume = 146,
place = {United States},
year = {Mon Jul 01 00:00:00 EDT 1996},
month = {Mon Jul 01 00:00:00 EDT 1996}
}