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Title: Effects of PCBs on liver ultrastructure and monooxygenase activities in Japanese quail

The effect of environmental pollutants such as PCBs and DDT on avian species is well documented. It is proven that chronic high level PCB intoxication perturbs calcium metabolism in birds, affecting eggshell thickness. PCBs have an impact on the liver. which accumulates high levels of toxicants. These induce drug-metabolizing enzyme activities in quail (Coturnix coturnix), herring gull (larus argentatus), and partridge (Prdix perdix). As these enzymes can degrade endogeneous molecules such as steroids, xenobiotics like PCBs can severely hinder birds` reproductive performance. PCBs induce damage such as regression of the testes, decreased sperm concentration, and altered embryonic development resulting in death or malformation of chicks. More ever, ultrastructural alterations linked with induction of these enzymes have been observed in the livers of PCB-contaminated chickens and ducks. This study examines the effects of Aroclor 1254 on liver morphology and glycogen content in quail, and related morphological modification to liver monoxygenase activities. 26 refs., 6 figs., 1 tab.
Authors:
;  [1]
  1. Univeriste de Liege, Liege (Belgium) [and others
Publication Date:
OSTI Identifier:
283214
Resource Type:
Journal Article
Resource Relation:
Journal Name: Bulletin of Environmental Contamination and Toxicology; Journal Volume: 56; Journal Issue: 5; Other Information: PBD: May 1996
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; LIVER; METABOLISM; MORPHOLOGY; BIRDS; POLYCHLORINATED BIPHENYLS; BIOLOGICAL EFFECTS; JAPAN; GLYCOGEN; ENZYMES