A new human IghV4.21-related pseudogene capable of VDJ rearrangement

Dunn-Walters, D K; Isaacson, P J; Spencer, J

doi:10.1007/s002510050070

Title: A new human IghV4.21-related pseudogene capable of VDJ rearrangement

Full Record
Other Related Research

Abstract

The IghViv family has been reported to consist of 13 different genes, only one of which is a pseudogene. The IghViv family member IghV4.21 is widely used, and is known to encode immunoglobulin specific for the red blood cell antigens I and i in germline configuration. We have previously reported a rearranged IghV4.21 gene, isolated from the marginal zone of normal human spleen, which has two large deletions in FR1 and FR2/CDR2. We have now identified the same IghV gene sequence rearranged to a different diversity (D) region, in plasma cells of the intestinal lamina propria in a different patient, suggesting that this sequence represents a new IghViv family pseudogene related to IghV4.21. 6 refs., 1 fig.

Authors:

Dunn-Walters, D K; Isaacson, P J; Spencer, J ^[1]

U.C.L.M.S., London (United Kingdom)

Publication Date:: Sun Sep 01 00:00:00 EDT 1996

OSTI Identifier:: 273490

Resource Type:: Journal Article

Journal Name:: Immunogenetics

Additional Journal Information:: Journal Volume: 43; Journal Issue: 5; Other Information: PBD: 1996

Country of Publication:: United States

Language:: English

Subject:: 55 BIOLOGY AND MEDICINE, BASIC STUDIES; GENES; STRUCTURE-ACTIVITY RELATIONSHIPS; GENE MUTATIONS; DNA SEQUENCING; DNA-CLONING; IMMUNOGLOBULINS; ANTIGENS; BLOOD CELLS; POLYMERASE CHAIN REACTION; PATIENTS

Citation Formats


                    Dunn-Walters, D K, Isaacson, P J, and Spencer, J. A new human IghV4.21-related pseudogene capable of VDJ rearrangement.  United States: N. p., 1996. 
        Web.  doi:10.1007/s002510050070.

Copy to clipboard


                    Dunn-Walters, D K, Isaacson, P J, & Spencer, J. A new human IghV4.21-related pseudogene capable of VDJ rearrangement.  United States.  https://doi.org/10.1007/s002510050070

Copy to clipboard


                    Dunn-Walters, D K, Isaacson, P J, and Spencer, J. 1996.  
        "A new human IghV4.21-related pseudogene capable of VDJ rearrangement".  United States.  https://doi.org/10.1007/s002510050070.

Copy to clipboard


                    
@article{osti_273490,

  title        = {A new human IghV4.21-related pseudogene capable of VDJ rearrangement},

  author       = {Dunn-Walters, D K and Isaacson, P J and Spencer, J},

  abstractNote = {The IghViv family has been reported to consist of 13 different genes, only one of which is a pseudogene. The IghViv family member IghV4.21 is widely used, and is known to encode immunoglobulin specific for the red blood cell antigens I and i in germline configuration. We have previously reported a rearranged IghV4.21 gene, isolated from the marginal zone of normal human spleen, which has two large deletions in FR1 and FR2/CDR2. We have now identified the same IghV gene sequence rearranged to a different diversity (D) region, in plasma cells of the intestinal lamina propria in a different patient, suggesting that this sequence represents a new IghViv family pseudogene related to IghV4.21. 6 refs., 1 fig.},

  doi          = {10.1007/s002510050070},

  url          = {https://www.osti.gov/biblio/273490},
  journal      = {Immunogenetics},
number       = 5,

  volume       = 43,

  place        = {United States},

  year         = {Sun Sep 01 00:00:00 EDT 1996},

  month        = {Sun Sep 01 00:00:00 EDT 1996}

}

Copy to clipboard

Journal Article:

https://doi.org/10.1007/s002510050070

Other availability

Find in Google Scholar

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Similar records in OSTI.GOV collections:

Structural repertoire in human V{sub L} pseudogenes of immunoglobulins: Comparison with functional germline genes and amino acid sequences

Journal Article Almagro, J; Lara-Ochoa, F; Dominguez-Martinez, V - Immunogenetics

Antibody molecules are highly antigen-specific receptors of the immune system. Antigen-antibody interaction involves the antibody V{sub L} and V{sub H} domains, each composed of a framework whose structure is well conserved. The antigen-binding site is composed of six hypervariable loops, three from the V{sub L} domain and three from the V{sub H} domain: L1, L2, L3, and H1, H2, H3, respectively. Genetically, L1 and L2 are encoded by the V{sub L} gene, while L3 is produced by the recombination of an additional gene segment, A. In a similar way, H1 and H2 are encoded by the V{sub H} gene, andmore »« less
Deletional rearrangement in the human T-cell receptor. cap alpha. -chain locus

Journal Article de Villartay, J; Lewis, D; Hockett, R; ... - Proc. Natl. Acad. Sci. U.S.A.; (United States)

The antigen-specific receptor on the surface of mature T lymphocytes is a heterodimer consisting of polypeptides termed ..cap alpha.. and ..beta... In the course of characterizing human T-cell tumors with an immature (CD4/sup -/, CD8/sup -/) surface phenotype, the authors detected a 2-kilobase ..cap alpha..-related transcript. Analysis of cDNA clones corresponding to this transcript established that a genetic element (which they call TEA, for T early ..cap alpha..) located between the ..cap alpha..-chain variable- and joining-region genes had been spliced to the ..cap alpha.. constant region. The TEA transcript is present early in thymocyte ontogeny, and its expression declines duringmore »« less
https://doi.org/10.1073/pnas.84.23.8608
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I. 29

Journal Article Stavnezer, J; Marcu, K; Sirlin, S; ... - Mol. Cell. Biol.; (United States)

The B cell lymphoma I.29 consists of a mixture of cells expressing membrane-bound immunoglobulin M (IgM) (lambda) and IgA (lambda) of identical idiotypes. Whereas most of the cells express either IgM of IgA alone, 1 to 50% of the cells in this tumor express IgM and IgA simultaneously within the cytoplasm and on the cell membrane. When IgM/sup +/ cells are purified from the lymphoma and passaged in mice or cultured, a portion of the cells convert to IgA/sup +/. These properties suggest that some cells of the I.29 lymphoma may undergo immunoglobulin heavy chain switching, although it is alsomore »« less
https://doi.org/10.1128/MCB.2.8.1002
Human immunoglobulin C/sub lambda/6 gene encodes the Kern /sup +/Oz/sup -/ lambda chain and C/sub lambda/4 and C/sub lambda 5/ are pseudogenes

Journal Article Dariavach, P; Lefranc, G; Lefranc, M - Proc. Natl. Acad. Sci. U.S.A.; (United States)

Six nonallelic immunoglobulin lambda constant region genes have been previously characterized on a 40-kilobase stretch of DNA. The nucleotide sequences of the three upstream genes of this cluster (C/sub lambda/1, C/sub lambda/2, C/sub lambda/3) have been determined by other workers and shown to encode, respectively, the isotypic Mcg, Kern/sup -/Oz/sup -/, and Kern/sup -/Oz/sup +/ constant region of the lambda chains. In this paper, the authors report the sequence of the three downstream genes of this cluster and show that two of them (C/sub lambda/4 and C/sub lambda/5) are pseudogenes. However, C/sub lambda/6 encodes a Kern/sup +/Oz/sup -/ chain andmore »« less
https://doi.org/10.1073/pnas.84.24.9074
Molecular cloning and chromosomal localization of a pseudogene related to the human Acyl-CoA binding protein/diazepam binding inhibitor

Journal Article Gersuk, V; Rose, T; Todaro, G - Genomics

The acyl-CoA binding protein (ACBP) and the diazepam binding inhibitor (DBI) or endozepine are independent isolates of a single 86-amino-acid, 10-kDa protein. ACBP/DBI is highly conserved between species and has been identified in several diverse organisms, including human, cow, rat, frog, duck, insects, plants, and yeast. Although the genomic locus has not yet been cloned in humans, complementary DNA clones with different 5{prime} ends have been isolated and characterized. These cDNA clones appear to be encoded by a single gene. However, Southern blot analyses, in situ hybridizations, and somatic cell hybrid chromosomal mapping all suggest that there are multiple ACBP/DBI-relatedmore »« less
https://doi.org/10.1016/0888-7543(95)80047-P

Similar Records