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Title: Mapping of the gracile axonal dystrophy (gad) gene to a region between D5Mit197 and D5Mit113 on proximal mouse chromosome 5

Abstract

The gracile axonal dystrophy (gad) mouse, which shows hereditary sensory ataxia and motor paresis, has been morphologically characterized by the dying back type of axonal degeneration in the nerve terminals of dorsal root ganglion cells and motor neurons. In the present study, using an intraspecific backcross between gad and C57BL/6J mice, the gracile axonal dystrophy (gad) gene was mapped to a region between D5Mit197 and D5Mit113. Estimated distances between gad and D5Mit197 and between gad and D5Mit113 are 0.4 {plus_minus} 0.3 and 5.0 {plus_minus} 1.0 cM, respectively. The gene order was defined: centromere-D5Mit81-D5Mit233-D5Mit184/D5Mit254-D5Mit256-D5Mit197-gad-D5Mit113-D5Mit7. The mouse map location of the gad locus appears to be in a region homologous to human 4p15-p16. Our present data suggest that the nearest flanking marker D5Mit197 provides a useful anchor for the isolation of the gad gene in a yeast artificial chromosome contig. 19 refs., 2 figs.

Authors:
; ;  [1]
  1. National Institute of Nueroscience, Tokyo (Japan); and others
Publication Date:
OSTI Identifier:
273449
Resource Type:
Journal Article
Journal Name:
Genomics
Additional Journal Information:
Journal Volume: 27; Journal Issue: 3; Other Information: PBD: 10 Jun 1995
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; GENES; GENETIC MAPPING; CHROMOSOMES; MICE; HEREDITARY DISEASES; NERVOUS SYSTEM DISEASES; HYBRIDIZATION; HUMAN CHROMOSOMES; BIOLOGICAL MARKERS; CONTIGS

Citation Formats

Suh, J G, Yamanishi, T, and Matsui, K. Mapping of the gracile axonal dystrophy (gad) gene to a region between D5Mit197 and D5Mit113 on proximal mouse chromosome 5. United States: N. p., 1995. Web. doi:10.1006/geno.1995.1091.
Suh, J G, Yamanishi, T, & Matsui, K. Mapping of the gracile axonal dystrophy (gad) gene to a region between D5Mit197 and D5Mit113 on proximal mouse chromosome 5. United States. https://doi.org/10.1006/geno.1995.1091
Suh, J G, Yamanishi, T, and Matsui, K. 1995. "Mapping of the gracile axonal dystrophy (gad) gene to a region between D5Mit197 and D5Mit113 on proximal mouse chromosome 5". United States. https://doi.org/10.1006/geno.1995.1091.
@article{osti_273449,
title = {Mapping of the gracile axonal dystrophy (gad) gene to a region between D5Mit197 and D5Mit113 on proximal mouse chromosome 5},
author = {Suh, J G and Yamanishi, T and Matsui, K},
abstractNote = {The gracile axonal dystrophy (gad) mouse, which shows hereditary sensory ataxia and motor paresis, has been morphologically characterized by the dying back type of axonal degeneration in the nerve terminals of dorsal root ganglion cells and motor neurons. In the present study, using an intraspecific backcross between gad and C57BL/6J mice, the gracile axonal dystrophy (gad) gene was mapped to a region between D5Mit197 and D5Mit113. Estimated distances between gad and D5Mit197 and between gad and D5Mit113 are 0.4 {plus_minus} 0.3 and 5.0 {plus_minus} 1.0 cM, respectively. The gene order was defined: centromere-D5Mit81-D5Mit233-D5Mit184/D5Mit254-D5Mit256-D5Mit197-gad-D5Mit113-D5Mit7. The mouse map location of the gad locus appears to be in a region homologous to human 4p15-p16. Our present data suggest that the nearest flanking marker D5Mit197 provides a useful anchor for the isolation of the gad gene in a yeast artificial chromosome contig. 19 refs., 2 figs.},
doi = {10.1006/geno.1995.1091},
url = {https://www.osti.gov/biblio/273449}, journal = {Genomics},
number = 3,
volume = 27,
place = {United States},
year = {Sat Jun 10 00:00:00 EDT 1995},
month = {Sat Jun 10 00:00:00 EDT 1995}
}