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Title: cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region

Abstract

A new gene (239FB) with predominant and differential expression in fetal brain has recently been isolated from a chromosome 11p13-p14 boundary area near FSHB. The corresponding mRNA has an open reading frame of 294 amino acids, a 3` untranslated region of 1247 nucleotides, and a highly GC-rich 5` untranslated region. The coding and 3` UT sequence is specified by 6 exons within nearly 87 kb of isolated genomic locus. The 5` end region of the transcript maps adjacent to the only genomically defined CpG island in a chromosomal subregion that may be associated with part of the mental retardation of some WAGR (Wilms tumor, aniridia, genitourinary anomalies, and mental retardation) syndrome patients. In addition to nucleotide and amino acid similarity to an EST from a normalized infant brain cDNA library, the predicted protein has extensive similarity to Caenorhbditis elegans polypeptides of, as yet, unknown function. The 239FB locus is, therefore, likely part of a family of genes with two members expressed in human brain. The extensive conservation of the predicted protein suggests a fundamental function of the gene product and will enable evaluation of the role of the 239FB gene in neurogenesis in model organisms. 48 refs., 4 figs., 1more » tab.« less

Authors:
; ; ;  [1]
  1. Children`s Hospital and Department of Pediatrics, Boston, MA (United States)
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
258293
Resource Type:
Journal Article
Journal Name:
Genomics
Additional Journal Information:
Journal Volume: 29; Journal Issue: 2; Other Information: PBD: 20 Sep 1995
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; GENES; DNA SEQUENCING; STRUCTURE-ACTIVITY RELATIONSHIPS; BIOLOGICAL EVOLUTION; GENETIC MAPPING; TRANSCRIPTION; BRAIN; GENE REGULATION; HUMAN CHROMOSOMES; HEREDITARY DISEASES; FETUSES; NUCLEOTIDES; EXONS; AMINO ACIDS; NEMATODES; SPLICING; DNA HYBRIDIZATION; FLUORESCENCE

Citation Formats

Schwartz, F, Eisenman, R, Knoll, J, and Bruns, G. cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region. United States: N. p., 1995. Web. doi:10.1006/geno.1995.9973.
Schwartz, F, Eisenman, R, Knoll, J, & Bruns, G. cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region. United States. https://doi.org/10.1006/geno.1995.9973
Schwartz, F, Eisenman, R, Knoll, J, and Bruns, G. 1995. "cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region". United States. https://doi.org/10.1006/geno.1995.9973.
@article{osti_258293,
title = {cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region},
author = {Schwartz, F and Eisenman, R and Knoll, J and Bruns, G},
abstractNote = {A new gene (239FB) with predominant and differential expression in fetal brain has recently been isolated from a chromosome 11p13-p14 boundary area near FSHB. The corresponding mRNA has an open reading frame of 294 amino acids, a 3` untranslated region of 1247 nucleotides, and a highly GC-rich 5` untranslated region. The coding and 3` UT sequence is specified by 6 exons within nearly 87 kb of isolated genomic locus. The 5` end region of the transcript maps adjacent to the only genomically defined CpG island in a chromosomal subregion that may be associated with part of the mental retardation of some WAGR (Wilms tumor, aniridia, genitourinary anomalies, and mental retardation) syndrome patients. In addition to nucleotide and amino acid similarity to an EST from a normalized infant brain cDNA library, the predicted protein has extensive similarity to Caenorhbditis elegans polypeptides of, as yet, unknown function. The 239FB locus is, therefore, likely part of a family of genes with two members expressed in human brain. The extensive conservation of the predicted protein suggests a fundamental function of the gene product and will enable evaluation of the role of the 239FB gene in neurogenesis in model organisms. 48 refs., 4 figs., 1 tab.},
doi = {10.1006/geno.1995.9973},
url = {https://www.osti.gov/biblio/258293}, journal = {Genomics},
number = 2,
volume = 29,
place = {United States},
year = {Wed Sep 20 00:00:00 EDT 1995},
month = {Wed Sep 20 00:00:00 EDT 1995}
}