Voltammetric determination of ruthenium in the form of complexes with biologically active ligands
- Kazan` State Univ., Moscow (Russian Federation); and others
The interest in the analytical chemistry of ruthenium and its compounds has recently been increasing. Ruthenium compounds can be used an antitumor agents and in the treatment of tuberculosis and fungal infections. It has been suggested that there is a specific relationship between the reduction potentials of the compounds and their biological activity. Of greatest interest among the biologically active compounds are the compounds with nitrogen-containing heterocycles. In order to obtain information on the degree of oxidation of the central atom in the complexes and to select the optimum conditions for the determination of the mono- and bi-nuclear complexes of ruthenium compounds with biologically active ligands such as imidazole (Im), histidine (His), benzimidazole (BIm) and its methyl derivative [1,2(CH{sub 3}){sub 2} - BIm], benzohyroxamic acid (Bha), and 1-phenyl-2-methylamino-1-propanol or ephedrine (Eph) in the present work, the authors studied their electrochemical behavior at dropping mercury (dme) and a platinum electrodes. 6 refs., 1 fig., 2 tabs.
- OSTI ID:
- 255234
- Journal Information:
- Journal of Analytical Chemistry, Vol. 46, Issue 8; Other Information: PBD: 10 Feb 1992; TN: Translated from Zhurnal Analiticheskoi Khimii; 46: No. 8, 1573-1577(Aug 1991)
- Country of Publication:
- United States
- Language:
- English
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