The ubiquitous mitochondrial creatine kinase gene maps to a conserved region on human chromosome 15q15 and mouse chromosome 2 bands F1-F3
- Univ. of Nijmegen (Netherlands)
- Radboud Hospital Univ., Nijmegan (Netherlands)
Members of the creatine kinase isoenzyme family (CKs; EC 2.7.3.2) are found in mitochondria and specialized subregions of the cytoplasm and catalyze the reversible exchange of high-energy phosphoryl between ATP and phosphocreatine. At least four functionally active genes, which encode the distinct CK subunits CKB, CKM, CKMT1 (ubiquitous), and CKMT2 (sarcomeric), and a variable number of CKB pseudogenes have been identified. Here, we report the use of a CKMT1 containing phage to map the CKMT1 gene by in situ hybridization on both human and mouse chromosomes.
- OSTI ID:
- 255232
- Journal Information:
- Genomics, Vol. 24, Issue 1; Other Information: PBD: 1 Nov 1994
- Country of Publication:
- United States
- Language:
- English
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