Failure to find a chromosome 18 pericentric linkage in families with schizophrenia

Journal Article · Mon Dec 18 00:00:00 EST 1995 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320600609· OSTI ID:254407

De Lisi, L E; Shields, G ^[1]; Lehner, T ^[2]

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1. SUNY Stony Brook, NY (United States)
2. Columbia Univ. and New York State Psychiatric Institute, New York, NY (United States); and others

A recent report of a possible linkage of bipolar affective disorder to a pericentric region of chromosome 18 initiated the present investigation to search for a similar linkage in 32 families with schizophrenia. The results of a study using 5 markers mapped to this region show negative lod scores and only weak evidence for any linkage by nonparametric analyses. If the previously reported finding is a true positive linkage for bipolar disorder, then either it is unlikely to be related to the genetics of schizophrenia, or the proportion of families linked to this region is small. 12 refs., 4 tabs.

• Sponsoring Organization: USDOE
• OSTI ID: 254407
• Journal Information: American Journal of Medical Genetics, Vol. 60, Issue 6; Other Information: PBD: 18 Dec 1995
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
HUMAN CHROMOSOME 18
GENETIC MAPPING
GENES
MENTAL DISORDERS
PATIENTS
HEREDITARY DISEASES
GENETICS
BIOLOGICAL MARKERS
STATISTICS