Characterization of the PSG11 gene

McLenachan, P A; Rutherfurd, K J; Beggs, K T

doi:10.1006/geno.1994.1395

Title: Characterization of the PSG11 gene

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Abstract

The pregnancy-specific {beta}{sub 1}-glycoproteins (PSG) form the major group of proteins synthesized in the human placenta. There are over 30 proteins in the family, encoded by 11 genes located on chromosome 19q13.1-13.3. The genes can be divided into three subgroups based on the C-terminal exons expressed. The subgroup 1 genes have been well characterized. In this study the organization and sequence of a complete, functional, subgroup 3 gene is described. It contains the C-terminal exons, C{sub w}, C{sub t}, and C{sub s}, which are expected from the transcripts characterized. Downstream from these exons are sequences homologous to the C-termini of the subgroup 1 type genes. This demonstrates that the subgroup 1, 2, and 3 genes are related via insertions/deletions. Comparison of the C-terminal sequences of the three subgroups of genes shows that the subgroup 2 and 3 genes are more closely related than, and are distinct from, the subgroup 1 genes. 38 refs., 3 figs.

Authors:

McLenachan, P A; Rutherfurd, K J; Beggs, K T ^[1]

Massey Univ., Palmerston North (New Zealand); and others

Publication Date:: Fri Jul 15 00:00:00 EDT 1994

OSTI Identifier:: 249992

Resource Type:: Journal Article

Journal Name:: Genomics

Additional Journal Information:: Journal Volume: 22; Journal Issue: 2; Other Information: PBD: 15 Jul 1994

Country of Publication:: United States

Language:: English

Subject:: 55 BIOLOGY AND MEDICINE, BASIC STUDIES; GLYCOPROTEINS; GENES; HUMAN CHROMOSOME 19; GENETIC MAPPING; PLACENTA; METABOLISM

Citation Formats


                    McLenachan, P A, Rutherfurd, K J, and Beggs, K T. Characterization of the PSG11 gene.  United States: N. p., 1994. 
        Web.  doi:10.1006/geno.1994.1395.

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                    McLenachan, P A, Rutherfurd, K J, & Beggs, K T. Characterization of the PSG11 gene.  United States.  https://doi.org/10.1006/geno.1994.1395

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                    McLenachan, P A, Rutherfurd, K J, and Beggs, K T. 1994.  
        "Characterization of the PSG11 gene".  United States.  https://doi.org/10.1006/geno.1994.1395.

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@article{osti_249992,

  title        = {Characterization of the PSG11 gene},

  author       = {McLenachan, P A and Rutherfurd, K J and Beggs, K T},

  abstractNote = {The pregnancy-specific {beta}{sub 1}-glycoproteins (PSG) form the major group of proteins synthesized in the human placenta. There are over 30 proteins in the family, encoded by 11 genes located on chromosome 19q13.1-13.3. The genes can be divided into three subgroups based on the C-terminal exons expressed. The subgroup 1 genes have been well characterized. In this study the organization and sequence of a complete, functional, subgroup 3 gene is described. It contains the C-terminal exons, C{sub w}, C{sub t}, and C{sub s}, which are expected from the transcripts characterized. Downstream from these exons are sequences homologous to the C-termini of the subgroup 1 type genes. This demonstrates that the subgroup 1, 2, and 3 genes are related via insertions/deletions. Comparison of the C-terminal sequences of the three subgroups of genes shows that the subgroup 2 and 3 genes are more closely related than, and are distinct from, the subgroup 1 genes. 38 refs., 3 figs.},

  doi          = {10.1006/geno.1994.1395},

  url          = {https://www.osti.gov/biblio/249992},
  journal      = {Genomics},
number       = 2,

  volume       = 22,

  place        = {United States},

  year         = {Fri Jul 15 00:00:00 EDT 1994},

  month        = {Fri Jul 15 00:00:00 EDT 1994}

}

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