Occurrence of metastases in beagles with skeletal malignancies induced by internal irradiation
- Univ. of Utah School of Medicine, Salt Lake City, UT (United States); and others
Metastases from malignant bone tumors often are responsible for the fatal effects of these cancers. Characteristics of primary skeletal malignancies in beagles injected with bone-seeking radionuclides were studied by Thurman (1971) and summarized by Thurman et al. (1971). There were 212 tumors in 186 of these dogs for which we subsequently received information on bone tumor metastases. Evaluation of bone and soft tissue slides from these animals allowed us to compare parameters reported previously with the occurrence of grossly apparent bone tumor metastases. Data included growth-rate of the primary tumor, volume of the primary tumor at death, sex of the animal, growth period of the primary tumor, degree of calcification of the primary tumor, skeletal location of the primary tumor, cumulative radiation dose to the skeleton, dose equivalent to the skeleton, and year of death. For most of the comparisons, no significant differences could be established between dogs with and without metastases. However, tumor volume at death appeared to be correlated with probability of metastasis (p < 0.05), with the larger tumors being associated with higher rates of metastasis. Comparisons of dogs with and without metastases as a function of tumor growth-rate did not, for the most part, yield significantly different results between groups. 10 refs., 11 tabs.
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC02-76EV00119; AC04-76EV01013
- OSTI ID:
- 249872
- Journal Information:
- Health Physics, Vol. 66, Issue 3; Other Information: PBD: Mar 1994
- Country of Publication:
- United States
- Language:
- English
Similar Records
Distribution of skeletal malignancies in beagles injected with {sup 239}Pu citrate
Primary bone neoplasms in beagle dogs exposed by inhalation to aerosols of plutonium-238 dioxide