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Title: Histopathology and {sup 241}Am microdistribution in skeletal USTUR case 246

Abstract

Histopathology and qualitative autoradiography studies were undertaken on bone removed at autopsy from USTUR Case 246. The histopathology examination revealed extensive bone marrow peritrabecular fibrosis and decreased cellularity in most samples. In addition, histological indicators suggest that bone cell turnover was suppressed at most sites, although turnover was found to be essentially normal in a vertebral body sample. The autoradiographic studies showed that bone turnover that had occurred resulted in the redistribution of americium within bone. However, surface deposits of americium remained conspicuous at many sites, particularly those with low bone growth activity. A few percent of the americium was present in the bone marrow. the dosimetric and toxicology findings indicate that current assumptions about the metabolic behavior of bone-seeking radionuclides are likely to be unrealistically simplistic. 15 refs., 9 figs.

Authors:
;  [1];  [2];  [3]
  1. AEA Technology, Oxfordshire (United Kingdom)
  2. Univ. of Manchester Medical School (United Kingdom)
  3. Washington State Univ., Richland, WA (United States)
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
229658
Resource Type:
Journal Article
Journal Name:
Health Physics
Additional Journal Information:
Journal Volume: 69; Journal Issue: 3; Other Information: PBD: Sep 1995
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; 55 BIOLOGY AND MEDICINE, BASIC STUDIES; AMERICIUM 241; TISSUE DISTRIBUTION; INHALATION; SKIN ABSORPTION; MAN; RADIONUCLIDE KINETICS; HANFORD RESERVATION; RADIATION ACCIDENTS; BONE TISSUES; AUTORADIOGRAPHY; DOSIMETRY; BIOLOGICAL RADIATION EFFECTS; OCCUPATIONAL EXPOSURE; AUTOPSY; CONTAMINATION; ACUTE EXPOSURE; SKELETON; DOSE RATES; BONE MARROW; FIBROSIS; HISTOLOGY; PATHOLOGY

Citation Formats

Priest, N D, Humphreys, J A.H., Freemont, A, and Kathren, R L. Histopathology and {sup 241}Am microdistribution in skeletal USTUR case 246. United States: N. p., 1995. Web. doi:10.1097/00004032-199509000-00004.
Priest, N D, Humphreys, J A.H., Freemont, A, & Kathren, R L. Histopathology and {sup 241}Am microdistribution in skeletal USTUR case 246. United States. https://doi.org/10.1097/00004032-199509000-00004
Priest, N D, Humphreys, J A.H., Freemont, A, and Kathren, R L. 1995. "Histopathology and {sup 241}Am microdistribution in skeletal USTUR case 246". United States. https://doi.org/10.1097/00004032-199509000-00004.
@article{osti_229658,
title = {Histopathology and {sup 241}Am microdistribution in skeletal USTUR case 246},
author = {Priest, N D and Humphreys, J A.H. and Freemont, A and Kathren, R L},
abstractNote = {Histopathology and qualitative autoradiography studies were undertaken on bone removed at autopsy from USTUR Case 246. The histopathology examination revealed extensive bone marrow peritrabecular fibrosis and decreased cellularity in most samples. In addition, histological indicators suggest that bone cell turnover was suppressed at most sites, although turnover was found to be essentially normal in a vertebral body sample. The autoradiographic studies showed that bone turnover that had occurred resulted in the redistribution of americium within bone. However, surface deposits of americium remained conspicuous at many sites, particularly those with low bone growth activity. A few percent of the americium was present in the bone marrow. the dosimetric and toxicology findings indicate that current assumptions about the metabolic behavior of bone-seeking radionuclides are likely to be unrealistically simplistic. 15 refs., 9 figs.},
doi = {10.1097/00004032-199509000-00004},
url = {https://www.osti.gov/biblio/229658}, journal = {Health Physics},
number = 3,
volume = 69,
place = {United States},
year = {Fri Sep 01 00:00:00 EDT 1995},
month = {Fri Sep 01 00:00:00 EDT 1995}
}