Propagation-based phase-contrast tomography for high-resolution lung imaging with laboratory sources

Journal Article · Tue Mar 15 00:00:00 EDT 2016 · AIP Advances

DOI:https://doi.org/10.1063/1.4943898· OSTI ID:22611579

Krenkel, Martin; Töpperwien, Mareike; Salditt, Tim ^[1]; Dullin, Christian ^[2]; Alves, Frauke ^[2]

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1. Institute for X-Ray Physics, University of Göttingen, 37077 Göttingen (Germany)
2. Institute of Diagnostic and Interventional Radiology, University Medical Center Göttingen, 37075 Göttingen (Germany)

We have performed high-resolution phase-contrast tomography on whole mice with a laboratory setup. Enabled by a high-brilliance liquid-metal-jet source, we show the feasibility of propagation-based phase contrast in local tomography even in the presence of strongly absorbing surrounding tissue as it is the case in small animal imaging of the lung. We demonstrate the technique by reconstructions of the mouse lung for two different fields of view, covering the whole organ, and a zoom to the local finer structure of terminal airways and alveoli. With a resolution of a few micrometers and the wide availability of the technique, studies of larger biological samples at the cellular level become possible.

• OSTI ID: 22611579
• Journal Information: AIP Advances, Vol. 6, Issue 3; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA); ISSN 2158-3226
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
BIOMEDICAL RADIOGRAPHY
CONTRAST MEDIA
COVERINGS
FINE STRUCTURE
LIQUID METALS
LUNGS
MICE
RESOLUTION
TOMOGRAPHY
WAVE PROPAGATION