Specialized probes based on hydroxyapatite calcium for heart tissues research by atomic force microscopy
- St. Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University), Kronverkskii pr. 49, St. Petersburg, 197101 (Russian Federation)
- Military Medical Academy named after S.M. Kirov, Academic Lebedev str. 6, St. Petersburg, 194044 (Russian Federation)
The new specialized AFM-probes with hydroxyapatite structures for atomic force microscopy of heart tissues calcification were created and studied. A process of probe fabrication is demonstrated. The adhesive forces between specialized hydroxyapatite probe and endothelium/subendothelial layers were investigated. It was found that the adhesion forces are significantly higher for the subendothelial layers. We consider that it is connected with the formation and localization of hydroxyapatite in the area of subendothelial layers of heart tissues. In addition, the roughness analysis and structure visualization of the endothelial surface of the heart tissue were carried out. The results show high efficiency of created specialized probes at study a calcinations process of the aortic heart tissues.
- OSTI ID:
- 22609117
- Journal Information:
- AIP Conference Proceedings, Vol. 1748, Issue 1; Conference: STRANN 2016: 5. international conference on state-of-the-art trends of scientific research of artificial and natural nanoobjects, St. Petersburg (Russian Federation), 26-29 Apr 2016; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
- Country of Publication:
- United States
- Language:
- English
Similar Records
Evidence for thyroxine transport by the lung and heart capillary endothelium
Hydroxyapatite Nanoclusters in Subendothelial Structures of Aortic Demilunes of Patients with Calcified Aortic Stenosis