skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Permeability studies of redox-sensitive nitroxyl spin probes in corn oil using an L-band ESR spectrometer

Abstract

Electron spin resonance (ESR) studies were carried out for 2mM {sup 14}N labeled {sup 2}H enriched 3-methoxycarbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl (MC-PROXYL) and 3–carboxy-2,2,5,5,-tetramethyl-1-pyrrolidinyloxy (carboxy-PROXYL) in pure water and various concentrations of corn oil. The ESR parameters, such as the line width, hyperfine coupling constant, g-factor, rotational correlation time, partition parameter and permeability were reported for the samples. The line width broadening was observed for both nitroxyl radicals in corn oil solutions. The partition parameter for permeable MC-PROXYL in corn oil increases with increasing concentration of corn oil, which reveals that the nitroxyl spin probe permeates into the oil phase. From the results, the corn oil concentration was optimized as 50 % for phantom studies. The rotational correlation time also increases with increasing concentration of corn oil. The permeable and impermeable nature of nitroxyl spin probes was demonstrated. These results will be useful for the development of ESR/OMR imaging modalities in in vivo and in vitro studies.

Authors:
 [1];  [2]; ;  [3]
  1. Department of Physics, The American College, Madurai-625 002, Tamilnadu (India)
  2. Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka 812-8582 (Japan)
  3. Department of Physics, NMSSVN College, Madurai-625 019, Tamilnadu (India)
Publication Date:
OSTI Identifier:
22606254
Resource Type:
Journal Article
Journal Name:
AIP Conference Proceedings
Additional Journal Information:
Journal Volume: 1731; Journal Issue: 1; Conference: DAE solid state physics symposium 2015, Uttar Pradesh (India), 21-25 Dec 2015; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-243X
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; CONCENTRATION RATIO; CORN OIL; CORRELATIONS; COUPLING CONSTANTS; DEUTERIUM; ELECTRON SPIN RESONANCE; ELECTRONS; LANDE FACTOR; LINE WIDTHS; NITROGEN 14; NITROXYL RADICALS; PERMEABILITY; PHANTOMS; PYRROLIDINES; SPECTROMETERS; SPIN; WATER

Citation Formats

Jebaraj, D. David, Utsumi, Hideo, Asath, R. Mohamed, and Benial, A. Milton Franklin,. Permeability studies of redox-sensitive nitroxyl spin probes in corn oil using an L-band ESR spectrometer. United States: N. p., 2016. Web. doi:10.1063/1.4947650.
Jebaraj, D. David, Utsumi, Hideo, Asath, R. Mohamed, & Benial, A. Milton Franklin,. Permeability studies of redox-sensitive nitroxyl spin probes in corn oil using an L-band ESR spectrometer. United States. https://doi.org/10.1063/1.4947650
Jebaraj, D. David, Utsumi, Hideo, Asath, R. Mohamed, and Benial, A. Milton Franklin,. 2016. "Permeability studies of redox-sensitive nitroxyl spin probes in corn oil using an L-band ESR spectrometer". United States. https://doi.org/10.1063/1.4947650.
@article{osti_22606254,
title = {Permeability studies of redox-sensitive nitroxyl spin probes in corn oil using an L-band ESR spectrometer},
author = {Jebaraj, D. David and Utsumi, Hideo and Asath, R. Mohamed and Benial, A. Milton Franklin,},
abstractNote = {Electron spin resonance (ESR) studies were carried out for 2mM {sup 14}N labeled {sup 2}H enriched 3-methoxycarbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl (MC-PROXYL) and 3–carboxy-2,2,5,5,-tetramethyl-1-pyrrolidinyloxy (carboxy-PROXYL) in pure water and various concentrations of corn oil. The ESR parameters, such as the line width, hyperfine coupling constant, g-factor, rotational correlation time, partition parameter and permeability were reported for the samples. The line width broadening was observed for both nitroxyl radicals in corn oil solutions. The partition parameter for permeable MC-PROXYL in corn oil increases with increasing concentration of corn oil, which reveals that the nitroxyl spin probe permeates into the oil phase. From the results, the corn oil concentration was optimized as 50 % for phantom studies. The rotational correlation time also increases with increasing concentration of corn oil. The permeable and impermeable nature of nitroxyl spin probes was demonstrated. These results will be useful for the development of ESR/OMR imaging modalities in in vivo and in vitro studies.},
doi = {10.1063/1.4947650},
url = {https://www.osti.gov/biblio/22606254}, journal = {AIP Conference Proceedings},
issn = {0094-243X},
number = 1,
volume = 1731,
place = {United States},
year = {Mon May 23 00:00:00 EDT 2016},
month = {Mon May 23 00:00:00 EDT 2016}
}